| 药用植物内生放线菌多样性及天然活性物质研究进展 |
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| 引用本文： | 郑有坤,刘凯,熊子君,李文均,徐丽华,赵立兴.药用植物内生放线菌多样性及天然活性物质研究进展[J].中草药,2014,45(14):2089-2099. |
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| 作者姓名： | 郑有坤 刘凯 熊子君 李文均 徐丽华 赵立兴 |
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| 作者单位： | 云南大学 云南省微生物研究所 西南微生物多样性教育部重点实验室, 云南 昆明 650091;云南大学 云南省微生物研究所 西南微生物多样性教育部重点实验室, 云南 昆明 650091;云南大学 云南省微生物研究所 西南微生物多样性教育部重点实验室, 云南 昆明 650091;云南大学 云南省微生物研究所 西南微生物多样性教育部重点实验室, 云南 昆明 650091;云南大学 云南省微生物研究所 西南微生物多样性教育部重点实验室, 云南 昆明 650091;云南大学 云南省微生物研究所 西南微生物多样性教育部重点实验室, 云南 昆明 650091 |
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| 基金项目： | 国家自然科学基金资助项目（U0932601，21062028）；云南大学校基金（2010ZD001） |
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| 摘 要： | 药用植物是人类生存和发展的重要资源。内生放线菌广泛存在于药用植物组织中，具有丰富的物种多样性，是植物微生态系统的重要组成部分。一些内生放线菌可产生和宿主植物相同或相似的天然活性物质。因此，利用内生放线菌生产抗菌、抗肿瘤等天然活性物质，不仅为新药的研发提供了新的途径，还能有效保护珍稀、濒危药用植物资源，具有重要的生态学意义和经济价值。总结了近年来药用植物内生放线菌的多样性、天然活性物质生物合成相关基因和天然活性物质多样性等方面的研究进展，以期为药用植物内生放线菌的研究提供参考。
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| 关 键 词： | 内生放线菌 药用植物资源 天然活性物质 小单孢菌属 链霉菌属 拟诺卡氏菌属 物种多样性 马杜拉放线菌 黄花蒿 研究进展 |
| 收稿时间： | 2013/11/22 0:00:00 |
Research progress on biodiversity of endophytic actinobacteria in medicinal plants and their bioactive substances |
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| ZHENG You-kun,LIU Kai,XIONG Zi-jun,LI Wen-jun,XU Li-hua and ZHAO Li-xing.Research progress on biodiversity of endophytic actinobacteria in medicinal plants and their bioactive substances[J].Chinese Traditional and Herbal Drugs,2014,45(14):2089-2099. |
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| Authors: | ZHENG You-kun LIU Kai XIONG Zi-jun LI Wen-jun XU Li-hua and ZHAO Li-xing |
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| Institution: | Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China;Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China;Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China;Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China;Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China;Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China |
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| Abstract: | Medicinal plants are important bio-resources for human existence and development. Endophytic actinobacteria with rich biodiversity, widely existing inside the tissues of medicinal plants, are important components of plant micro-ecosystems, and some can produce same or similar bioactive substances generated by their host plants. Therefore, utilizing endophytic actinobacteria to produce bioactive substances with antimicrobial and antitumor effects can not only provide a new way for the development of new drugs, but also effectively protect the endangered medicinal plant resources. Furthermore, this process has important ecological significance and economic value. In this review, research advances on the diversity of endophytic actinobacteria, genes related to natural product biosynthesis, and diversity of their natural bioactive substances are summarized, and a reference for the research of endophytic actinobacteria from the medicinal plants is provided. |
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| Keywords: | medicinal plant endophytic actinobacteria biosynthesis genetic screening natural bioactive substances |
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