帕罗西汀与氯米帕明治疗60例强迫症疗效分析

目的:对比帕罗西汀与氯米帕明治疗强迫症的疗效及不良反应。方法:60例患者随机分为两组,帕罗西汀组31例,男、女分别为14例和17例,年龄22～45岁,帕罗西汀20～60 mg/d,1次/d;氯米帕明组29例,男、女分别为13例和16例,年龄20～48岁,氯米帕明150～300 mg/d,分2次口服。疗程为6周。用Yale-Brown强迫量表评定疗效,药物副反应量表(TESS)评定不良反应。结果:6周治疗后,帕罗西汀组有效率58.1%,氯米帕明组有效率58.6%,两组差异无统计学意义(P>0.05);帕罗西汀组不良反应总分明显低于氯米帕明组,差异有统计学意义(P<0.01),帕罗西汀常见的不良反应是口干、食欲减退、恶性、头痛等。结论:帕罗西汀治疗强迫症有效且安全,不良反应少而轻。

Clinical analysis of paroxetine and clomipramine in the treatment of 60 cases with obsessive compulsive disorder

Objective To compare the effects and adverse reactions of paroxetine and clomipramine in the treatment of obsessive-compulsive disorder.Method Total 60 patients were randomly divided into two groups,paroxetine group(31 cases,male of 14 and female of 17,aged 22 to 45 years old):paroxetine 20 ~ 60 mg/d;clomipramine group(29 cases,male of 13 and female of 16,aged 20 to 48 years old):clomipramine 150~300 mg/d,for 2 times per day.Treatment for 6 weeks.Using Yale-Brown obsessive compulsive scale to assess efficacy,adverse drug reaction scale(TESS) to assess adverse reactions.Results After 6 weeks′ treatment,the efficiency of paroxetine group was 58.1%,clomipramine group with an efficiency of 58.6%,no significant difference was found between the two groups(P>0.05);the side reaction score in paroxetine group was significantly lower than clomipramine group(P<0.01).The common adverse reactions of paroxetine were dry mouth,loss of appetite and malignant headache.Conclusion Paroxetine treating obsessive compulsive disorder is safe and effective,with less adverse reactions.