MC9204对大鼠心肌肥厚模型的影响

目的：观察新的二氢吡啶类钙拮抗剂ＭＣ９２０４对大鼠心肌肥厚的影响。方法：建立大鼠腹主动脉狭窄左室肥厚（ＬＶＨ）模型，并给予新的二氢吡啶类钙拮抗剂ＭＣ９２０４治疗３ｍｏ，观察在鼠ＬＶＨ时心肌重量指数，心室厚度，氧自由基（ＯＦＲ）、心肌酶释放等的变化。

Effects of MC9204 on cardiac hypertrophy model in rats

To study effects of MC9204, a dihydropy-ridine calcium antagonist, on cardiac hypertrophy model in rats. Methods: Rat abdomino aorta was narrowed for 3 months to establish a left ventricular hypertrophy (LVH) model, and given by an administration of MC9204 to investigate its effects. Heart weight/body weight (HW/BW), left ventricular weight/body weight (LVW/BW) , left ventricular wall thickness (LVWT) , ventricular septal thickness (VST) and makmdialdehyde(MDA), superoxide dismutase (SOD), creatine kinase (CPK) and lactic dehydrogenase (LDH) were measured. Results: HW/BW, LVW/BW, LVWT, VST of LVHC(LVH control) were significantly higher than those ofoperation control (P<0. 01), which suggested LVH model was successful. MDA, LDH, CPK were statistically increased whereas SOD was decreased in LVHO(P<0. 01), The changes were improved by MC9204 administration(P< 0. 01). Conclusion: Oxygen free radical(OFR) is increased while clearance of it is decreased in LVH, indicating OFR may play a role in the development of LVH. MC9204 had beneficial effects on LVH, which may be related to its block of calcium entry, decrease of the cardiac burden and the keeping of the balance of OFR production and clearance system.