异丙托溴铵联合布地奈德呼吸机雾化吸入治疗COPD急性加重期患者的疗效观察

目的:研究异丙托溴铵联合布地奈德呼吸机雾化吸入对慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗的临床效果.方法:选择2015年1月至2016年1月在我院收治的AECOPD患者120例,按简单随机分组法将患者分为研究组和对照组,每组各60例.两组均给予综合治疗,对照组患者在此基础上吸入雾化的复方异丙托溴铵加以治疗,研究组患者在对照组患者的基础上在加用布地奈德的雾化吸入进行治疗,对两组患者的临床治疗效果进行检测并进行对比,对两组患者喘息、气促以及肺部体征消失的时间、咳嗽缓解时间进行统计并对比;对两组患者治疗前后的肺部功能指标以及动脉血气指标进行监控检测并加以比较.结果:治疗后研究组患者临床病征好转所用时间短于对照组,差异具有统计学意义(P<0.05);两组治疗后PaCO2以及PaO2等动脉血气指标和治疗前相比较,患者动脉血气指标有明显的改善,与治疗前进行对比,FEV1/FVC、FEV占预计值百分比等指标更优,并且与对照组的改善程度相比较,治疗组更优,差异具有统计学意义(P<0.05).结论:复方异丙托溴铵联合布地奈德呼吸机雾化吸入对AECOPD患者的治疗效果明显,对于患者临床病征的缓解速度较快,明显改善患者肺功能指标和动脉血气指标,值得在临床推广应用.

Study on Treatment Plan of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Objective:To study the clinical effect of isopropyl supporting bromide and budesonide vent-ilator atomization inhalation on patients with acute exacerbation of chronic obstructive pulmonary disease ( AE-COPD) . Methods:120 cases of AECOPD in our hospital from January 2015 to January 2016 were randomly divided into study group and control group according to the random number table method, 60 cases in each group. Both groups were given comprehensive treatment, the patients in control group on the basis of the inha-lation of nebulized compound isopropyl tiotropium treatment, patients in the study group the control group based in Canada with budesonide atomization inhalation treatment, Linchuan treatment effect of two groups of patients were detected and compared, of two groups of patients with wheezing, shortness of breath and lung signs disappeared time, cough relieving time contrast and statistics;the two groups before and after treatment in patients with pulmonary function and arterial blood gas index for monitoring and detecting and compared. Results: The study group of patients with clinical symptom recovery time after treatment, was significantly shorter than that of the control group ( P<0.05);after treatment in the two groups of PaO2 and PaCO2 arterial blood gas index and treatment before compared, arterial blood gas indexes of patients have significantly im-proved, before and after treatment were compared, FEV1 / FVC, FEV1 percentage of predicted value of such indicators as the percentage significantly better and compared with the control group of the degree of improve-ment, the treatment group better ( P<0.05) . Conclusion:Compound isopropyl supporting bromide and budes-onide ventilator atomization inhalation in patients with AECOPD treatment effect is more obvious, palliation in patients with clinical symptoms of faster, significantly improved patients with pulmonary function and arterial blood gas index, it is worth in clinical application.