Cobas601对中年非甲状腺疾病患者血清FT3、FT4、TSH测定结果分析

目的：通过研究中年人群患者血清当中存留的血清游离三碘甲状腺原氨酸（ FT3）、血清游离甲状腺素（FT4）以及促甲状腺激素（TSH）含有量探讨中年人群甲状腺功能情况。方法使用电化学发光的检测手段对130名无甲状腺疾病的中年患者进行FT3、FT4和TSH检测，并对非正常情况出现率、不同性别、年龄（30～36岁、37～40岁、41～45岁）测定值及非正常情况出现率进行分析。结果 FT3以及FT4含量减少的发生机率分别为19 j．9％和7．7％，TSH升高的发生机率为34．3％。女性FT3含量要比男性偏高（ P ＜0．05），FT4在不同性别间差异无统计学意义（ P ＞0．05），不同性别FT3、TSH非正常发生率比较，差异有统计学意义（ P ＜0．05）。 FT3会伴随着年龄的增加含量会逐渐减少（ P ＜0．05），不同年龄组TSH含量比较，差异有统计学意义（ P ＜0．05）。不同的年龄FT3出现含量降低发生率比较，差异有统计学意义（ P ＜0．05），而FT4不会随着年龄的改变出现变化（ P ＞0．05）。结论在中年患者当中，随着年龄的逐渐增加，其甲状腺功能出现异常的情况会比较容易发生，其重点表现在FT3含量降低，以及TSH含量增加。

Analysis for the detection results of serum FT3, FT4 and TSH in middle aged patients without thyroid diseases

Objective To investigate the thyroid functional status in middle aged patients without thyroid diseases by detecting the serum levels of free triiodothyronine ( FT3 ) , serum free thyroxine ( FT4 ) and thyroid stimulating hormone (TSH).Methods The serum levels of FT3,FT4 and TSH were detected and analyzed by electrochemiluminescence method in 181 middle aged patients without thyroid diseases .Results The incidence of decrease of FT 3 and FT4 contents was 19.9%,7.7%, respectively, and the probability of increase of TSH was 34.3%.The levels of FT3 in females were significantly higher than those of males ( P <0.05),however,there were no significant differences in the levels of FT4 betweem females and males ( P >0.05).Furthermore there were significant differences in the incidence of abnormality FT 3, TSH between males and females ( P <0.05).The levels of FT3 would gradually decrease along with the growth of patient ’s age ( P <0.05).There were significant differences in the levels of TSH among different age groups ( P <0.05).There was a significant difference in the incidence of decrease of FT 3 contents among different age groups ( P <0.05).However the levels of FT4 were not changed along with the growth of patient ’ s age ( P >0.05).Conclusion The incidence of thyroid function abnormality is higher in middle aged patients along with the growth of patient ’ s age, which manifests mainly the decrease of FT3 levels and increase of TSH levels .