少腹逐瘀汤联合康妇消炎栓治疗急性盆腔炎临床疗效及对血清炎性因子的影响

目的：：探讨少腹逐瘀汤联合康妇消炎栓辅助治疗急性盆腔炎的临床疗效，减轻机体炎症反应。方法：选择符合标准的患者78例，随机分为观察组40例和对照组38例，均给予常规抗生素治疗，观察组加用少腹逐瘀汤及康妇消炎栓，比较二者临床疗效及血清TNF－α、IL－1β、IL－8及CRP 水平变化。结果：两组患者治疗前血清 TNF－α、IL－1β、IL－8及 CRP 水平相似，差异无统计学意义( P>0.05)；疗程结束时，两组血清TNF－α、IL－1β、IL－8及CRP 水平较治疗前均下降，但是观察组患者较对照组下降幅度更大，差异有统计学意义(P<0.05)。观察组总有效率92.50％；对照组总有效率71.05％，差异有统计学意义( P<0.05)。结论：急性盆腔炎在常规抗生素治疗的基础上，加用少腹逐瘀汤及康妇消炎栓，可有效降低患者体内炎症反应，提高临床治疗效果，促进患者预后。

Clinical Efficacy of Shaofu Zhuyu Tang Combined with Kangfu Anti-inflammatory Suppository in Treatment of Acute Pelvic Inflammatory Disease and the Effects on Serum Inflammatory Factors

Objective:To investigate the clinical efficacy of Shaofu Zhuyu Tang combined with Kangfu anti-inflammatory suppository in treatment of acute pelvic inflammatory disease, and to lighten the inflammato-ry reaction of the body. Methods:A total of 78 eligible patients were selected and randomly divided into ob-servation group and control group, with 40 patients in the observation group and 38 patients in the control group. All the patients were routinely treated with antibiotics, but the patients of the observation group were given with Shaofu Zhuyu Tang and Kangfu anti-inflammatory suppository additionally, and the clinical effica-cies and changes in serum TNF-α, IL-1β, IL-8 and CRP levels were compared between the two groups. Re-sults:Before the therapies, the patients of the two groups had similar serum TNF-α, IL-1β, IL-8 and CRP levels, and the differences were statistically insignificant ( P>0.05) . At the end of course of treatment, the pa-tients of both groups had decreased serum TNF-α, IL-1β, IL-8 and CRP levels when compared with those before the therapies, but the patients of the observation group had greater decreasing extents than the control group, and the differences were statistically significant ( P<0.05) . Of the observation group, 20 patients were cured, 10 patients were responsive to the therapy excellently, 7 patients were responsive to the therapy, and 3 patients were unresponsive to the therapy;the total effective rate was 92.50%. While of the control group, 12 patients were cured, 9 patients were responsive to the therapy excellently, 6 patients were responsive to the therapy, and 11 patients were unresponsive to the therapy;the total effective rate was 71.05%;the difference was statistically significant ( P<0.05) . Conclusion:Based on routine use of antibiotics, additional use of Sha-ofuzhuyu tang and Kangfu anti-inflammatory suppository can effectively lighten the inflammatory reaction, ele-vate clinical efficacy, and improve the prognosis in patients with acute pelvic inflammatory disease.