辛伐他汀联合辅酶Q10对慢性心衰大鼠心功能及心室重构的影响

目的：：探索辛伐他汀联合辅酶Q10对慢性心衰大鼠心功能及心室重构的影响。方法：利用腹主动脉缩窄法制作雄性SD大鼠慢性心力衰竭模型，随机分为模型组、辛伐他汀组、辅酶Q10组、联合用药组，另设假手术组，每组8只大鼠，测量各组大鼠血流动力学参数( LVEDP、± dp/dtmax )；计算左心室质量指数( LVMI)、检测左心室心肌胶原容积分数( CVF％)；观察左心室心肌组织病理学改变。结果：与模型组相比，辛伐他汀组、辅酶Q10组和联合用药组LVEDP、LVMI和CVF等三项指标降低，差异具有统计学意义( P<0.01)；且联合用药组较辛伐他汀、辅酶Q10单用组改变差异具有统计学意义( P<0.05)。结论：辛伐他汀与辅酶Q10联合应用较两药单独应用改善心衰大鼠心功能、抑制心室重塑作用明显。

Effects of Simvastatin Combined CoenzymeQ10 on Ventricular Remodeling and Cardiac Function in Rats with CHF

Objective:To investigate the effects of simvastatin combined coenzymeQ10 on ventricular re-modeling and cardiac function in rats with chronic heart failure ( CHF) . Methods:40 SD rats were randomly divided into five groups:sham-operated group, coenzymeQ10 group, simvastatin group, simvastatin combined coenzymeQ10 group and model group. Coarctation of abdominal aorta ( CCA) except for the shame-operated group. Testing hemodynamic of left ventricular end-diastolic diameter press (LVEDP),left ventricular pres-sure rise and fall ( ±dp/dtmax) ,left ventricular mass/body mass ( LVMI);HE and Masson’ s trichrome stai-ning for morphology. Results:Compared with model group, hemodynamic analysis revealed that left ventricu-lar end-diastolic pressure ( LVEDP ) were significantly lower in simvastatin group, coenzymeQ10, simvastatin combined coenzymeQ10 group(P<0.01), left ventricular pressure rise and fall increased remarkable(P<0.01);In addition, left ventricular mass/body mass ( LVMI) and collagen volume fraction ( CVF%) was de-creased sharply(P<0.01).CoenzymeQ10 group,simvastatin combined coenzymeQ10 groups improved CHF re-markable than rest groups (P< 0.05).Conclusion: All of these results verify that treatment with simvastatin combined coenzymeQ10 has more obvious effects on improving heart function of rats with cardiac remodeling and inhibit ventricular remodeling.