| The determination and significance of C/EBP in cells of liver cancer and different liver tissues |
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| 引用本文： | 徐砺新,隋延仿,王文亮,张荣美,刘彦仿,胡敏,顾建人. The determination and significance of C/EBP in cells of liver cancer and different liver tissues[J]. 中国人民解放军军医大学学报, 1993, 0(4) |
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| 作者姓名： | 徐砺新 隋延仿 王文亮 张荣美 刘彦仿 胡敏 顾建人 |
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| 作者单位： | Department of Pathology Fourth Military Medical University，Department of Pathology，Fourth Military Medical University，Department of Pathology，Fourth Military Medical University，Anhui Traditional Chinese Medicine College，Department of Pathology，Fourth Military Medical University，Department of Pathology，Fourth Military Medical University，Shanghai Cancer Institute |
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| 摘 要： | C/EBP is a sequence-specific DNA-binding protein.In order to identify its distribu-tion,localization and function,immunocytochemical technique(ABC method)was done usinganti-C/EBP polypeptide antibodies 1103~#,425~# in liver specimens from 20 normal adult,5neonatal,6 patients with hepatitis,25 patients with liver cirrhosis,80 patients with hepatocellu-lar carcinoma(40 cases were associated with surrounding nontumorous tissues)and 26 patientswith cholangiocarcinoma(15 cases were associated with surrounding nontumorous tissues).Theresults showed that C/EBP was diffusely distributed in nuclei and cytoplasm of differentiated liv-er cells and very low or undetectable in liver cancer cells.The expression of C/EBP was in pro-portion to differentiated degree of tumor cells,and was obviously weaker than that in surround-ing nontumorous tissues.C/EBP positive staining has also been found in regenerating epithelialcells of bile ductules.The results suggested that C/EBP might play an important role in estab-lishing and maintaining the differentiation of liver cells and might exert an inhibiting effect againsttransformation of liver cells and proliferation of neoplastic tissue.
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The determination and significance of C/EBP in cells of liver cancer and different liver tissues |
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| Xu Lixin Sui Yanfang Wang Wenliang Zhang Rongmei Liu Yah fang Hu Min Gu Jianren. The determination and significance of C/EBP in cells of liver cancer and different liver tissues[J]. Journal of Medical Colleges of PLA(China), 1993, 0(4) |
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| Authors: | Xu Lixin Sui Yanfang Wang Wenliang Zhang Rongmei Liu Yah fang Hu Min Gu Jianren |
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| Affiliation: | Xu Lixin Sui Yanfang Wang Wenliang Zhang Rongmei Liu Yah fang Hu Min Gu Jianren~1Department of Pathology,Fourth Military Medical University~2Anhui Traditional Chinese Medicine College ~3Shanghai Cancer Institute |
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| Abstract: | C/EBP is a sequence-specific DNA-binding protein.In order to identify its distribu- tion,localization and function,immunocytochemical technique(ABC method)was done using anti-C/EBP polypeptide antibodies 1103~#,425~# in liver specimens from 20 normal adult,5 neonatal,6 patients with hepatitis,25 patients with liver cirrhosis,80 patients with hepatocellu- lar carcinoma(40 cases were associated with surrounding nontumorous tissues)and 26 patients with cholangiocarcinoma(15 cases were associated with surrounding nontumorous tissues).The results showed that C/EBP was diffusely distributed in nuclei and cytoplasm of differentiated liv- er cells and very low or undetectable in liver cancer cells.The expression of C/EBP was in pro- portion to differentiated degree of tumor cells,and was obviously weaker than that in surround- ing nontumorous tissues.C/EBP positive staining has also been found in regenerating epithelial cells of bile ductules.The results suggested that C/EBP might play an important role in estab- lishing and maintaining the differentiation of liver cells and might exert an inhibiting effect against transformation of liver cells and proliferation of neoplastic tissue. |
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| Keywords: | C/EBP hepatoma liver cirrhosis immunocytochemistry differentiation proliferration |
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