| T细胞亚群在脓毒症中的免疫代谢反应 |
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| 引用本文： | 郭品豪,薄禄龙,卞金俊.T细胞亚群在脓毒症中的免疫代谢反应[J].国际麻醉学与复苏杂志,2020(2):212-216. |
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| 作者姓名： | 郭品豪 薄禄龙 卞金俊 |
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| 作者单位： | 海军军医大学长海医院麻醉学部 |
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| 基金项目： | 国家自然科学基金面上项目(81671939,81871579)。 |
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| 摘 要： | 脓毒症的发病机制涉及免疫细胞的异常激活和免疫抑制。免疫抑制即使在脓毒症恢复后仍会持续。免疫抑制阶段CD4^+T细胞、CD8^+T细胞、Th17细胞和γδT细胞减少并伴有调节性T细胞(regulatory T cells,Tregs)的增加,同时还影响免疫细胞代谢。文章总结分析CD4^+T细胞、CD8^+T细胞、Th17细胞、Tregs和γδT细胞在脓毒症导致免疫抑制过程中的代谢反应及其对免疫反应的影响。探究免疫代谢对T细胞功能的调控作用,有助于发现脓毒症期间T细胞免疫代谢的相关靶点,并开发治疗脓毒症免疫的代谢调控疗法。
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| 关 键 词： | 脓毒症 免疫抑制 免疫代谢 T细胞 |
Immunometabolism of different T cell subsets during sepsis |
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| Guo Pinhao,Bo Lulong,Bian Jinjun.Immunometabolism of different T cell subsets during sepsis[J].international journal of anesthesiology and resuscitation,2020(2):212-216. |
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| Authors: | Guo Pinhao Bo Lulong Bian Jinjun |
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| Institution: | (Faculty of Anesthesiology,Changhai Hospital,Naval Military Medical University,Shanghai 200433,China) |
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| Abstract: | Aberrant activation of innate immune cells and immunosuppression are part of the pathogenesis of sepsis.The loss of CD4^+T cells,CD8^+T cells,Th17 cells,γδT cells,upregulation of regulatory T cells(Tregs)and aberrant immune cell metabolism can be detected in the stage of immunosuppression.Summarizing and analyzing the influence of immunometabolism of immune cells(CD4^+T cells,CD8^+T cells,Th17,Tregs andγδT)during sepsis induced immunosuppression on regulating the function of T cells are helpful to investigate potential target of the immunometabolism of T cells.This review is benefit to explore novel immunometabolism therapeutic method to treat sepsis. |
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| Keywords: | Sepsis Immunosuppression Immunometabolism T cells Fund program:National Natural Science Foundation of China |
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