丙泊酚与睡眠障碍

睡眠是维持人体正常生理功能的一个重要生理活动,随着人们生活节奏的加快,睡眠障碍的人数也在逐渐增多。目前许多研究表明全身麻醉药可以通过作用于睡眠‐觉醒环路引起意识消失,从而在短时间内对人体的睡眠产生一定的影响。丙泊酚是全身麻醉药的一种,进一步观察和研讨丙泊酚对睡眠障碍患者产生的影响,有助于了解丙泊酚对患者预后和康复产生的影响,但是丙泊酚与睡眠障碍关系的研究却少之又少。文章通过介绍睡眠产生的机制和调节因素、睡眠障碍产生的机制和影响因素,总结丙泊酚对睡眠的影响及导致意识消失的分子靶点,综述丙泊酚对睡眠障碍可能产生的影响及机制。

Propofol and sleep disorders

Sleep is an important physiological activity to maintain normal physiological functions of human body.With the acceleration of human life rhythm,the number of sleep disorders is increasing gradually at the same time.At present,many studies have shown that general anesthetics can cause loss of consciousness by acting on the sleep‐wake circuit,and thus have a certain impact on human sleep in a short period of time.Propofol is one of the general anesthetics.Further observation and discussion of the effects of propofol on patients with sleep disorders will help to understand the effects of propofol on the prognosis and rehabilitation of patients.But studies on propofol and sleep disorders are rare.In this paper,by introducing the mechanism and regulating factors of sleep,the mechanism and influencing factors of sleep disorder,effect of propofol on sleep and its molecular targets leading to loss of consciousness are summarized.Also,the possible effects and underlying mechanisms of propofol on sleep disorders are summarized.