| 循环肿瘤细胞检测走近临床 |
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| 引用本文： | 蔡贞,郑磊,刘京萍,潘世扬.循环肿瘤细胞检测走近临床[J].中华检验医学杂志,2020(2):111-114. |
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| 作者姓名： | 蔡贞 郑磊 刘京萍 潘世扬 |
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| 作者单位： | 南方医科大学南方医院检验科;南京医科大学第一附属医院江苏省人民医院检验学部 |
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| 基金项目： | 国家自然科学基金(81672100);广东省省级科技计划项目(2016A010105006)。 |
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| 摘 要： | 循环肿瘤细胞(CTC)作为肿瘤转移的"种子",在肿瘤的早期辅助诊断、免疫治疗、预后评估等方面具有重要的临床应用价值。随着对CTC了解的不断深入,其应用研究已经从细胞数量走向了分子分型和细胞测序时代。然而CTC检测的标准化尚处于初步阶段,机遇和挑战并存。本文就CTC检测的现状及在临床应用中面临的挑战作一论述,并针对未来发展方向提出相关建议。
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| 关 键 词： | 肿瘤细胞 循环 液体活检 遗传异质性 参考标准 生物标记 肿瘤 |
Circulating tumor cell detection approaching to clinical application |
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| Cai Zhen,Zheng Lei,Liu Jingping,Pan Shiyang.Circulating tumor cell detection approaching to clinical application[J].Chinese Journal of Laboratory Medicine,2020(2):111-114. |
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| Authors: | Cai Zhen Zheng Lei Liu Jingping Pan Shiyang |
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| Institution: | (Department of Laboratory Medicine,NanFang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Laboratory Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China) |
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| Abstract: | As"seeds"of tumor metastasis,circulating tumor cell(CTC)has important clinical application value in early diagnosis,immunotherapy and prognosis evaluation of tumors.With a deep understanding of CTC,its applied research has switched from cell enumeration to the molecular typing and single-cell sequencing.However,the standardization of CTC detection is still at a primary stage,opportunities and challenges coexist.This paper will review the current status and challenges in clinical applications of CTC detection,and make some suggestions for future development. |
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| Keywords: | Neoplastic cells circulating Liquid biopsy Genetic heterogeneity Reference standards Biomarkers tumor |
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