舒缓保湿修护霜在异维 A 酸软胶囊治疗痤疮中的皮肤保护作用

目的 观察舒缓保湿修护霜在异维A酸软胶囊治疗痤疮过程中的皮肤保护作用。方法 选择2020年 1月-2021年3月我院皮肤科门诊收治的60例中度痤疮患者为研究对象，均系统使用异维A酸软胶囊口服治 疗，治疗2周后随机分为观察组及对照组，各30例。观察组外用舒缓保湿修护霜，对照组外用氧化锌软 膏，两组均继续接受同等剂量异维A酸软胶囊口服治疗，比较两组面部异常状态及不适症状评分、皮肤属 性及角质层含水量，记录观察组满意度及不良反应发生情况。结果 观察组面部皮肤异常状态及自觉不适 症状评分低于对照组（P＜0.05）；观察组面部主观皮肤属性评分高于对照组（P＜0.05）；观察组客观平 滑度、水润度、柔韧性属性评分高于对照组（P＜0.05）；两组客观光泽度属性比较，差异无统计学意义 （P＞0.05）；观察组皮肤角质层含水量高于对照组（P＜0.05）；观察组治疗满意度较高，未发生不良反 应。结论 舒缓保湿修护霜可以缓解因异维A酸软胶囊治疗痤疮而产生的发红、干燥等皮肤不适症状，改善 皮肤状态，且安全性及患者满意度较高。

Protective Effect of Soothing Moisturizing Care Cream in the Treatment of Acne with Isotretinoin Soft Capsules

Objective To observe the skin protective effect of soothing moisturizing care cream in the treatment of acne with isotretinoin soft capsules. Methods From January 2020 to March 2021, 60 patients with moderate acne admitted to the dermatology clinic of our hospital were selected as the research objects. All patients were treated with isotretinoin soft capsule orally. After 2 weeks of treatment, they were randomly divided into observation group and control group, with 30 cases in each group. The observation group was treated with soothing moisturizing care cream for external use, and the control group was treated with zinc oxide ointment for external use. Both groups continued to receive the same dose of isotretinoin soft capsule for oral treatment. The scores of facial abnormal state and discomfort symptoms, skin attributes and stratum corneum water content were compared between the two groups. The satisfaction and adverse reactions of the observation group were recorded. Results The scores of facial skin abnormal state and subjective discomfort symptoms in the observation group were lower than those in the control group (P<0.05). The facial subjective skin attribute score of the observation group was higher than that of the control group (P<0.05). The scores of objective smoothness, water wettability and flexibility in the observation group were higher than those in the control group (P<0.05). There was no significant difference in objective glossiness between the two groups (P>0.05). The water content of skin stratum corneum in the observation group was higher than that in the control group (P<0.05). The observation group had higher satisfaction with treatment and no adverse reactions occurred. Conclusion Soothing moisturizing care cream can relieve the skin discomfort symptoms such as redness and dryness caused by the treatment of acne with isotretinoin soft capsules, improve the skin condition, and has high safety and patient satisfaction.