中国甘肃地区汉族白血病易感性与HLA-Ⅰ类抗原之间的相关性

目的：探讨中国甘肃地区汉族白血病易感性与HLA-Ⅰ抗原之间的相关性，找出白血病的易感基因。方法：采用特异性寡核苷酸探针杂交(PCR/SSO)法，初步对43名白血病病人和66名健康对照进行了HEA-Ⅰ抗原分型。结果：经过SSPS10．0统计软件分析，中国甘肃地区汉族白血病患者HLA-A’01和HLA-A‘11基因的统计结果分别为x^2=6．350，P=0．028、X^2=5．574，P=0．018。显示相关性。结论：中国甘肃地区汉族人群中HLA-A01和HLA-A’11与白血病有相关性。

HLA class-Ⅰ antigens in Gansu Chinese Han nationality with leukemia

Objective:Host genetic factors are known to contribute to disease susceptibility.They may also be important in defining the pattern of disease presentation and progression,as well as its overall prognosis.However,no consistent HLA class-Ⅰ associations have been established in leukemia by PCR/SSOP in Gansu Chinese Han.Such studies have been reported in other counties,with conflicting results.This is the first PCR-based HLA class-Ⅰ association study in northwestern Chinese Han nationality leukemia.Methods:Compared HLA class-Ⅰ in 43 Chinese leukemia patients and 66 healthy Chinese controls as determined by polymerase chain reaction and sequence-specific olignucletide probe hybridization(PCR/SSO) DNA analysis.The present findings imply that HLA-associated genetic factors influence the risk for the development of leukemia.