| 左旋氧氟沙星滴眼及球结膜下注射的兔眼通透性比较 |
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| 引用本文： | 孙航,杨淑群,周远大,何海霞. 左旋氧氟沙星滴眼及球结膜下注射的兔眼通透性比较[J]. 重庆医科大学学报, 2004, 29(5): 625-628 |
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| 作者姓名： | 孙航 杨淑群 周远大 何海霞 |
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| 作者单位： | 重庆医科大学病毒性肝炎研究所;重庆医科大学第二临床学院眼科,重庆,400010;重庆医科大学临床学院临床药理教研室,重庆,400016 |
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| 摘 要： | 目的:比较左旋氧氟沙星(LVFX)点眼和球结膜下注射后家兔眼各组织的药物浓度及药代动力学参数.方法:将0.3%LVFX滴入或球结膜下注射入兔眼,在不同时点取角膜、房水、虹膜-睫状体、晶状体、玻璃体等组织,用高效液相色谱法测定组织中的药物浓度.结果:球结膜下注射LVFX后,不但在角膜、虹膜-睫状体中具有更高的药物浓度,而且在晶状体和玻璃体内也有较高的药物浓度,与滴眼组相比较,有显著差异(P＜0.01或P＜0.05).结论:球结膜下注射LVFX较滴入法更有利于治疗严重的眼部感染.
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| 关 键 词： | 左旋氧氟沙星 药物分布 药代动力学 高效液相色谱法 |
| 文章编号： | 0253-3626(2004)05-0625-04 |
| 修稿时间： | 2003-11-28 |
Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration |
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| SUN Hang,et al. Intraocular penetration of levofloxacin in rabbit eyes following topical and subconjunctival administration[J]. Journal of Chongqing Medical University, 2004, 29(5): 625-628 |
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| Authors: | SUN Hang et al |
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| Abstract: | Objective:To compare the ocular tissue concentrations and pharmacokinetic parameters in rabbit's eyes after topically and subconjunctivally administrated with levofloxacin (LVFX).Methods:The concentrations of LVFX in the cornea,aqueous humor,iris-ciliary body,lens and vitreous at different times were measured by high performance liquid chromatography after 0.3% LVFX were topically and subconjunctivally administrated into rabbits.Results:The penetration of LVFX into the cornea,iris-ciliary body,lens and vitreous after subconjunctival injection was significantly higher than that of topically applied one( P <0.01 or P <0.05).Conclusion:Subconjunctival LVFX could be more effective than topical administration in the treatment of severe eye infection. |
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| Keywords: | Levofloxacin Drug distribution Pharmacokinetics High performance liquid chromatography |
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