心理因素与卵巢癌的关系及其对神经内分泌的影响

目的探讨心理因素与卵巢癌发病之间的关系，并分析其神经内分泌激素及免疫因子的变化。方法采用对照研究的方法，运用临床心理评定量表（LES、CS、SSRS）对卵巢癌患者组(n=80)、卵巢良性肿瘤患者组(n=60)、健康对照组(n=60)病前遭遇的生活事件、应付方式、社会支持进行问卷调查，同时用ELISA方法检测各组被调查者血清中的皮质酮（CS）、去甲肾上腺素（NE）、白介素-2（IL-2）的水平,分析其与卵巢癌患者发病之间的关系。结果卵巢癌患者负性生活事件频数明显高于其他两组；积极应对、客观支持、主观支持、对支持的利用度均低于其他两组，尤低于健康对照组；而消极应对明显高于其他两组。卵巢癌患者血清CS、NE值均高于同期其他两组，与负性事件、消极应对呈正相关；而IL-2值低于其他两组，与负性事件、消极应对呈负相关。结论负性生活事件、低的社会支持、不良应对方式可通过引起神经内分泌及细胞因子等改变，影响卵巢恶性肿瘤发生。

Relationship between Psychosocial Factors and Ovarian Cancer and Its Impact on Neuro-endocrine

Objective To explore the relationship between the psychosocial factors and ovarian cancer occur rence, and to analyze its nerve-endocrine-immune factors change. Methods 80 patients with ovarian cancer patients and 60 patients with ovarian benign tumor and 60 healthy persons were asked to complete the Life Events Scale (LES),Trait Coping Styles Questionnaire (TCSQ),and Social Support Rating Scale (SSRS)，and examined the levels of serum CS、NE、IL-2 by mean of ELISA, to analyze the correlation between psychosocial factors and the incidence in patients with ovarian cancer. Results The frequency of negative life events,negative coping style among the patients with ovarian tumor were significantly higher than those of controls. The score of positive coping style and social support were much lower. The levels of serum CS、NE of the patients with ovarian tumor were clearly higher than those of controls,and they are positively correlated with negative events and negative response;but the levels of serum IL-2 were much lower than those of controls, and were negatively correlated with negative events and negative response. Conclusion Negative life events, low social support, poor coping styles can affect the occurrence of ovarian cancer by changing body neuroendocrine and cytokines.