h-prune Is an Independent Prognostic Marker for Survival in Esophageal Squamous Cell Carcinoma |
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Authors: | Tsuyoshi Noguchi MD PhD Naohide Oue MD PhD Shinsuke Wada MD PhD Kazuhiro Sentani MD Naoya Sakamoto MD Akira Kikuchi MD PhD Wataru Yasui MD PhD |
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Institution: | (1) Department of Oncological Science (Surgery II), Oita University Faculty of Medicine, Oita 879-5593, Japan;(2) Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan;(3) Department of Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551, Japan |
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Abstract: | Background The human homologue of Drosophila prune (PRUNE, which encodes h-prune) protein interacts with glycogen synthase kinase 3 and promotes cell motility. The aim
of our study was to investigate the impact of immunohistochemically detected h-prune expression on the survival of patients
with esophageal squamous cell carcinoma (ESCC).
Methods Immunohistochemical staining of h-prune was performed for 205 surgically resected specimens of ESCC.
Results In total, 43 (21%) of 205 ESCC cases were positive for h-prune. h-prune-positive ESCC cases showed a more-advanced T stage
(P < 0.0001), N stage (P < 0.0001), and tumor stage (P < 0.0001) than h-prune-negative ESCC cases. In the group of 116 stage II and III ESCC cases, recurrence of ESCC was frequently
found in h-prune-positive cases. In patients with lung recurrence, the tumors were more likely to be h-prune positive than
h-prune negative. Univariate analysis revealed that T stage (P < 0.0001), N stage (P < 0.0001), tumor stage (P < 0.0001), and h-prune staining (P < 0.0001) were significant prognostic factors for survival. Multivariate analysis indicated that N stage (P = 0.0182) and h-prune staining (P < 0.0001) were independent predictors for survival.
Conclusions These results indicate that immunostaining of h-prune is useful to identify patients at high risk for recurrence or poor prognosis
associated with ESCC. |
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Keywords: | h-prune Esophageal squamous cell carcinoma (ESCC) Motility Metastasis Prognosis |
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