加压治疗减压病机理的实验研究

目的探讨加压治疗减压病的机理。方法在兔减压病(decompression sickness，DCS)发病后和发展到严重DCS时，人随动物立即被加压到0．5MPa，在压力下Doppler连续监测心前区，间断显微球结膜血管，观察动物行为。结果加压的疗效、循环系统内气泡的消除与微血管功能恢复的速度、程度呈相应关系。血管功能严重障碍或衰竭的动物，在加压和减压过程中，因微血管功能进行性障碍，使病情恶化。结论压力只能消除DCS发病时血液中气体过饱和的膨胀力，使有代偿功能的痉挛血管解痉，恢复血液循环，逆转DCS的发病过程。压力不能使功能严重障碍、衰竭的血管恢复功能、不能修复损伤组织，也不能直接消除循环系统内的气泡。

Experimental Study on Mechanism of Recompression Therapy of Decompression Sickness

Objective: To elucidate that recompression is the most efficient measure in removing the pathogenic factors. Method: When rabbits were suffering from severe DCS, their pressure were immediately compressed to 0.5 Mpa. Precordial region was monitored continuously with a Doppler flow meter, micrography of the bulbar conjunctiva was done intermittently and the behaviors of the animals were recorded. Result: Effects of therapeutic recompression and elimination of circulating bubbles were correlated to rate and extent of recovery of microvascular function. The animals' DCS with severe dysfunction or failure of blood vessels, DCS became worse owing to progressive impairment of microvascular function during recompression and decompression. Conclusion: The pressure could only cancel the tension provoked by supersaturated gas in the blood so as to relieve the spasm of the compensatory blood vessels, which can restore the blood circulation and reverse the developing course of the DCS. The pressure, however, couldn't recover the function of the blood vessels with severe dysfunction or failure, or repair the injured tissues, or eliminate the circulating bubbles directly.