| 锰对小鼠精子的损害作用 |
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| 引用本文： | 宣登峰,易建华,画伟. 锰对小鼠精子的损害作用[J]. 工业卫生与职业病, 2002, 28(1): 17-19 |
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| 作者姓名： | 宣登峰 易建华 画伟 |
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| 作者单位： | 西安交通大学医学院公共卫生系,陕西,西安,710061 |
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| 摘 要： | 目的 探讨低剂量锰对小鼠精子的损害作用。方法 用低剂量锰（2.5,5,10,20mg/kg)腹腔注射染毒昆明种小鼠，12周后对精子畸形率、活动率、精子总数、睾锰含量和睾丸系数进行观察。结果 精子总数、活动度、睾丸系数随染毒剂量升高而降低；精子畸形率、睾锰含量随染毒剂量增加而升高。结论氯化锰2.5mg/kg对精子仍有毒性损害作用，雄性小鼠精子总数对锰毒作用较敏感。
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| 关 键 词： | 锰 生殖毒性 精子损害 动物实验 职业卫生 |
| 文章编号： | 1000-7164(2002)01-0017-03 |
| 修稿时间： | 2001-04-16 |
Effect of Low Concentration Manganese on Reproductive Function of Mice |
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| XUAN Deng|feng,YI Jian|hua,HUA Wei. Effect of Low Concentration Manganese on Reproductive Function of Mice[J]. Industrial Health and Occupational Diseases, 2002, 28(1): 17-19 |
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| Authors: | XUAN Deng|feng YI Jian|hua HUA Wei |
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| Abstract: | Objective To study the effects of low concentration Mn exposure on male mice reproductive functions.Methods The morphology,activity,quantity of sperm,the level of Mn in testicle and the weight coefficient were investigated after a successive 12 weeks i p administration of Mn(2^5,5,10,20 mg/kg).Results Results showed that the quantity,activity and the weight coefficient were significantly decreased as the dose increased.The ratio of sperm deformity and the level of Mn in testicle were significantly increased as the dose increased.Conclusions It suggested that low concentration of Mn might have sperm toxicity in mice. |
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| Keywords: | Manganese Reproduction toxicity Sperm |
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