Delayed damaging effects of anthracycline antibiotics on the reproductive system of rats |
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| Authors: | E D Gol'dberg T G Borovskaya T I Fornina M G Skorokhodova M E Smirnova |
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| Institution: | (1) Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Siberian, USSR |
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| Abstract: | Destructive changes and disturbances of spermatogenesis are found to occur in the testes of Wistar rats 1 and 3 months after
a single injection of the anthracycline antibiotic pharmorubicin in the maximum permissible dose. The morphological picture
normalizes 6 months postinjection. Disturbances in reproductive function are observed as early as 3 months after treatment.
The number of dominant lethal mutations rises one month postinjection.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp. 55–58, January, 1996 |
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| Keywords: | anthracycline antibiotic pharmorubicin delayed effects testis |
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