| 乙醇对发育期小鼠海马神经元数量的影响 |
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| 引用本文： | 胡艳秋,蒋杞英,程相树,邓锦波.乙醇对发育期小鼠海马神经元数量的影响[J].河南大学学报(医学版),2007,26(3):20-22. |
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| 作者姓名： | 胡艳秋 蒋杞英 程相树 邓锦波 |
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| 作者单位： | 河南大学,神经生物学研究所,河南,开封,475004;河南大学,神经生物学研究所,河南,开封,475004;河南大学,神经生物学研究所,河南,开封,475004;河南大学,神经生物学研究所,河南,开封,475004 |
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| 基金项目： | 河南大学校科研和教改项目 |
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| 摘 要： | 目的:研究妊娠乙醇滥用对发育期海马神经元数量的影响。方法:采用C57BL/6 J小鼠,用胃饲乙醇方法建立妊娠乙醇滥用模型。对新生鼠(P0)、生后7 d(P7)、生后14 d(P14)小鼠海马进行N issl法染色,显微镜计数海马神经元的数量。结果:与对照组相比,低剂量组和高剂量组神经元明显减少(P<0.05);与低剂量组相比,高剂量组CA1区神经元明显减少(P<0.05);CA3区无明显差异(P>0.05)。结论:妊娠乙醇滥用可使发育期海马神经元明显减少。
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| 关 键 词： | 乙醇 海马 神经元数量 小鼠 |
| 文章编号： | 1672-7606（2007）03-0020-03 |
| 修稿时间： | 2007-05-23 |
Effects of the alcohol on neuronal number of hippocampus in developing mice |
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| Hu Yan-qiu,Jiang Qi-ying,Cheng Xiang-shu,Deng Jin-bo.Effects of the alcohol on neuronal number of hippocampus in developing mice[J].Journal of Henan University,2007,26(3):20-22. |
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| Authors: | Hu Yan-qiu Jiang Qi-ying Cheng Xiang-shu Deng Jin-bo |
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| Institution: | Institute of Neurobiology of Henan University, Henan Kaifeng 475004, China |
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| Abstract: | Objective: To investigate the effects of the alcohol on neuronal number of hippocampus in developing mice during pregnancy.Methods: Clean-grade C57B1/6J mices were used,Model of alcohol exposure was established by intragastric alcohol,neurons in hippocampus were examined by Nissl staining at P0、P7 and P14.The number of neurons was counted under microscope.Results: The number of neurons manifestly decreased in low-dose alcohol group and high-dose alcohol group(P<0.05),especially in CA1 of high-dose(P<0.05).Conclusion: The number of neurons in the developing hippocampus manifestly decrease by alcohol exposure during pregnancy.There may be a closely relation between hippocampal neurons and low intelligence. |
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| Keywords: | Alcohol Hippocampus Number of neurons mice |
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