Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro |
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| Authors: | Yamaji Kazuyo Sarker Krishna Pada Maruyama Ikuro Hizukuri Susumu |
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| Institution: | Department of Laboratory and Molecular Medicine, Faculty of Medicine, Kagoshima University, Kagoshima City, Japan. yamaji@m3.kufm.kagoshima-u.ac.jp |
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| Abstract: | The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease. |
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