| 川芎嗪对肝缺血再灌注大鼠线粒体功能的保护作用 |
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| 引用本文： | 孙经建 缪明永. 川芎嗪对肝缺血再灌注大鼠线粒体功能的保护作用[J]. 第二军医大学学报, 1996, 17(5): 434-436 |
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| 作者姓名： | 孙经建 缪明永 |
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| 作者单位： | 第二军医大学长海医院东方肝胆外科研究所 |
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| 摘 要： | 目的；评价川芎嗪对肝缺血再灌注后大鼠肝线粒体的影响，并探讨作用。方法；实验动物分为３组；阻断组。阻断＋川芎嗪组和假处理组。肝线粒体分离后以氧电极法测定其呼吸活性。结果；肝缺血再灌注后大鼠肝线粒仨呼吸比率、磷氧比值和氧化磷酸化效率均显著降低，应用川芎嗪能保持正常的线粒体功能。结论；川芎嗪具有保护缺血再灌注肝线粒体功能的作用。
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| 关 键 词： | 川芎嗪 肝 缺血再灌注 线粒体 川芎 |
The protective effect of tetramethylpyrazine on mitochondrial function in rat liver after ischemia and reperfusion |
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| Sun Jingjian, Miao Mingyong, Wu Mengchao, Wang Xuemin, Chen Han, Qian Guangxiang. The protective effect of tetramethylpyrazine on mitochondrial function in rat liver after ischemia and reperfusion[J]. Former Academic Journal of Second Military Medical University, 1996, 17(5): 434-436 |
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| Authors: | Sun Jingjian Miao Mingyong Wu Mengchao Wang Xuemin Chen Han Qian Guangxiang |
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| Abstract: | Objective:To evaluate the protective effect of tetramethylpyrazine, a Chinese medicine, on mitochondrial function in rat liver after ischemia-reperfusion. Methods: All rats were divided into 3 groups:sham operation,ischemia-reperfusion untreated,and ischemia-reperfusion tetramethylpyrazine treated.Hepatic mitochondria were isolated and mitochondrial respiratory activity was assayed in a Clark oxygen electrode. Results: Respiratory control ratio (RCR), ratio of P/O and oxidative phosphorylation rate (OPR) were significantly declined after ischemia-reperfusion in rat liver, as compared with the sham operative rat.Treatment with tetramethylpyrazine could maintain the normal mitochondrial function after ischemia-reperfusion. Conclusion: Tetramethylpyrazine has a protective effect on mitochondrial function in rat liver after ischemia and reperfusion. |
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| Keywords: | tetramethylpyrazine liver ischemia-reperfusion mitochondria |
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