急性有机磷农药中毒纳洛酮治疗120例临床观察

目的比较有机磷农药中毒常规治疗组和加用纳洛酮治疗组,以探讨纳洛酮能否提高抢救成功率,降低死亡率。方法120例有机磷农药中毒患者随机分为常规治疗组（对照组）和加用纳洛酮治疗组,比较其在中毒程度、治愈、死亡、阿托品中毒、反跳、中间综合征等方面的区别。结果纳洛酮治疗组治愈率明显高于对照组,差异有统计学意义（P〈0.05）,纳洛酮治疗组治疗中毒昏迷清醒时间较常规治疗组清醒时间短,两组比较差异有统计学意义（P〈0.05）。结论治疗有机磷农药中毒患者加用纳洛酮可明显降低病死率,缩短中毒患者清醒时间,并减少阿托品中毒发生。从而提示纳洛酮可提高抢救成功率。

Clinical Observation of 120 Cases in Acute Organophosphorus Poisoning Treated with Naloxone

Objective To compare routine treatment with naloxone in the treatment of organophosphorus poisoning in order to determine whether the addition of naloxone can increase the success rate of rescue and reduce mortality. Methods 120 patients with organophosphorus poisoning admitted in the emergency department of our hospital were randomly divided into two groups, one treated with routine therapy and the other with naloxone as additional treatment. The severity of poisoning, cure rate, mortality, atropinism, rebound and intermediate syndrome of both groups were compared. Results The cure rate in the naloxone group was significantly higher than that in the control group （P〈 0.05）. The coma duration in the naloxone group was significantly shorter than that in the routine therapy group （P〈 0.05）. Conclusion The addition naloxone in the treatment of patients with organophosphorus poisoning can significantly reduce the mortality, shorten the coma duration and decrease the incidence of atropinism as well, indicating that naloxone can improve the success of rescue.