珍珠散协同爱宝疗治疗重度宫颈糜烂的临床疗效与药物经济学研究

目的观察中药珍珠散协同爱宝疗浓缩液治疗重度官颈糜烂临床疗效和药物经济学效益。方法将有生育要求的Ⅲ度官颈糜烂患者111例随机分为治疗组和对照组，治疗组用中药珍珠散联合爱宝疗浓缩液治疗，对照组则单用爱宝疗浓缩液治疗，均每3d治疗一次。45d后，比较两组疗效、疗程及治疗费用。结果治疗组治愈率明显高于对照组（67．9％vs36．4％），差异有统计学意义（P〈0．05）。治疗组费用明显低于对照组（371．6±138．4）vs（483．6±36．6）]元（P〈0．01）。治疗组治疗时间比对照组显著缩短（32．4±12．1）vs（44．0±3．3）]d（P〈0．01）。治疗组中提前结束治疗患者多于对照组（35／56vs6／55，P〈0．05）。治疗组与对照组均未见副作用发生。结论珍珠散协同爱宝疗浓缩液治疗重度官颈糜烂疗效好，药物经济学效益高，值得临床推广。

Evaluation of Combination Therapy of Severe Cervical Erosion with Zhenzhusan and Albothyl

Objective To evaluate the efficacy of combination therapy of patients with severe cervical erosion with Zhenzhusan and Abothyl. Methods 111 Patients suffered from degree-Ⅲ cervical erosion were randomly divided into treatment group and control group. Patients in the treatment group were treated with Zhenzhusan and Abothyl. Patients in the control group were treated with Abothyl only. All patients received the treatment at 3 days interval for 45 days. The two groups were then compared for their efficacy and cost effectiveness. Results The percentage of patients recovered from the treatment was 67.9% in the treatment group and 36.4% in the control group （P〈0.05）. The cost for the treatment in the treatment group was significantly lower （￥371.6±138.4） than the control group （￥483.6±36.6, P〈 0.01 ）. The course of therapy in the treatment group was also significantly shorter （32.4±12.1 days） than the control group （44.0±3.3 days,P〈0.01 ）. 35 out of 56 patients in the treatment group had completed the treatment earlier than the scheduled time （control group, 6 out of 55 ,P〈0.05）. Side effects were not observed in both groups. Conclusion Combination therapy of severe cervical erosion patients with Zhenzhusan and Albothyl is cost-effective.