静脉药瘾者丙型肝炎病毒感染及其相关因素的分析

目的了解静脉药瘾者丙型肝炎病毒（HCV）感染状况及其影响因素。方法381例静脉药瘾者作为研究对象，采集血清，用酶联免疫吸附法（ELISA）和聚合酶链反应（PCR）观察HCV感染和常见的血源传播病毒的感染指标。结果静脉药瘾者中抗HCV阳性261人（68．5％），感染率与当地正常人群比较，差异有统计学意义（P〈0．01），单因素分析表明HCV感染与吸毒史长短、共用注射器者和重叠HIV／HBV感染相关。Logistic逐步回归分析主要因素是HIV感染、吸毒史和共用注射器。结论静脉药瘾者是HCV感染的高危人群，而吸毒史长、共用注射器和伴发HIV／HBV感染时，使机体易感性增高，静脉药瘾者是丙型肝炎的重点防治对象。

Extent of HCV Infection Among Intravenous Drug Users and the Relevant Factors

Objective To assess the extent of HCV infection among intravenous drug users （IVDU） and the relevant factors. Methods Serum samples from 102 normal subjects and 381 IVDU were collected and analyzed for anti- HCV, HBcAb, HBsAg, HBeAg and anti-HIV antibodies by ELISA. HCV-RNA was detected by Fluorescence Quantitative PCR. Results 68.5% of IVDU had the HCV infection. One-way ANOVA showed that HCV infection was associated with the history of drug addiction, the use of contaminated needles and HIV/HBV infection. Logistic regression analysis showed that the drug addition ancl the use of contaminated needle were the key factors contributing to HIV infection. Collusion The risk of HCV infection in IVDU is high. Individuals with the history of drug addiction, sharing of needles, and HIV/HBV co-infection are the target groups for HCV treatment.