148例新生儿眼结膜炎与产妇阴道病原感染相关性的分析

目的了解自然分娩产妇产道细菌性感染（不包括衣原体）对于新生儿眼结膜炎的发病影响，加强围产期保健，防止婴幼儿视力损害。方法对148例新生儿眼结膜炎患者作结膜囊渗出物细菌培养和药敏试验，根据培养结果将患儿分为A组：培养阴性（无菌生长）组，B组：培养阳性组（有菌生长），同时相应将A组、B组患儿母亲分为产妇A组和产妇B组，作阴道分泌物涂片革兰染色检查相对照。结果产妇A组检出病原菌者5例（17．2％），清洁度正常，未检出病原菌及滴虫者24例（82．8％）。患儿B组检出淋病奈瑟氏菌13株（10．9％），其它各属菌株106株（89．1％）。产妇B组涂片见有白细胞内外革兰阴性双球菌者11例（9．2％）；其它病原菌及念珠菌、滴虫感染者76例（63．9％），清洁度正常，未检出病原菌及滴虫者32例（26．9％）。产妇A组产道感染阳性率17．2％，B组阳性率73．1％，两者比较差异有极显著性（P〈0.001）。结论新生儿眼结膜炎与产妇产道感染有密切相关性，应加强对妊娠中晚期孕妇的生殖道感染防治，减少新生儿经产道感染的几率。

Analysis of the Relationship between and Vaginal Infection Conjunctivitis in Newborn Babies of Lying-in Women

Objective To examine the correlation between vaginal bacterial infection （excluding chlamydia infection） in women having natural delivery and the incidence of conjunctivitis in the newborn babies. Methods Microbiological analysis and drug-sensitivity tests were performed on the conjunctiva bag exudates from 148 newborn babies. According to the results of the tests, the newborns were divided into Group A （ negative in the bacterial culture） and Group B （positive in the bacterial culture）. There mothers were also divided into Group A and Group B accordingly to the Gram staining reaction. Results Pathogens were isolated from 5 mothers in the Group A （17.2%）, and the secretion was clear. 24 mothers （82.8%） were negative for trichomonad infection. 13 isolates of Neisseria gonorrhoeae and 106 other bacterial isolates were found in the Group B newbern babies. Gram-negative diplococcus was found in the samples from 11 （9.2%） Group B mothers. IntraceUular Gram-negative diplococcus was also seen. 76 （63.9%） Group B mothers had trichomonad infection and other bacterial infections, and the secretion was clear. 32 （26.9%） subjects were negative for infection. The infection rate of the Group A and Group B mothers was 17.2% and 73.1%, respectively. The difference in infection was significant （P〈0.001）. Conclusion There is a close correlation between vaginal infection and the development of conjunctivitis in newborn babies. Prevention of infection should be made, especially for the mothers at the middle and late periods of pregnancy.