Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus. |
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| Authors: | D R Higgs J S Wainscoat J Flint A V Hill S L Thein R D Nicholls H Teal H Ayyub T E Peto A G Falusi |
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| Institution: | D R Higgs, J S Wainscoat, J Flint, A V Hill, S L Thein, R D Nicholls, H Teal, H Ayyub, T E Peto, A G Falusi, et al. |
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| Abstract: | Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers. |
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