| 急性髓性白血病SHIP基因突变和SNP的研究 |
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| 引用本文： | 许家仁,李建勇,张苏江,黄峻. 急性髓性白血病SHIP基因突变和SNP的研究[J]. 江苏医药, 2006, 32(12): 1103-1104 |
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| 作者姓名： | 许家仁 李建勇 张苏江 黄峻 |
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| 作者单位： | 210029,南京医科大学第一附属医院;210029,南京医科大学第一附属医院;210029,南京医科大学第一附属医院;210029,南京医科大学第一附属医院 |
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| 摘 要： | 目的 研究急性髓性白血病（AML）患者含SH2肌醇磷脂酶（SHIP）基因突变和单核苷酸多态性（SNP）及其临床意义。方法 采用基因组PCR、RT-PCR和直接测序等方法，在72例AML患者中检测SHIP基因突变和SNP。结果 SHIPQ1153L为新发现的突变，阳性率1．4％。结论 SHIPQ1153L突变可能参与了继发性AML的分子发病机制。
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| 关 键 词： | 含SH2肌醇磷酸酯酶 突变 单核苷酸多态性 急性髓性白血病 |
| 收稿时间： | 2006-02-22 |
| 修稿时间： | 2006-02-22 |
A study on mutation and SNP of SHIP gene in acute myeloid leukemia |
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| XU Jiaren, LI Jianyong, ZHANG Sujiang,et al.. A study on mutation and SNP of SHIP gene in acute myeloid leukemia[J]. Jiangsu Medical Journal, 2006, 32(12): 1103-1104 |
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| Authors: | XU Jiaren LI Jianyong ZHANG Sujiang et al. |
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| Affiliation: | First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, CHINA |
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| Abstract: | Objective To study the mutation and single nucleotide polymorphism(SNP) of SH2-containing inositol phosphatase(SHIP) gene in acute myeloid leukemia(AML) patients and investigate the clinical significance. Methods The mutation and SNP of SHIP were detected by genomic PCR and RT-PCR,and directly sequenced in 72 AML patients. Results SHIP Q1153L was a novel mutation and the positive ratio was 1.4%. Conclusion The mutation of SHIP Q1153L maycontribute to molecular leukemogenesis of secondary AML. |
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| Keywords: | SH2-containing inositol phosphatase Mutation Single nucleotide polyrnorphism Acute myeloid leukemia |
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