可卡因-苯丙胺调节转录肽在缺血性脑损伤中的保护作用

可卡因-苯丙胺调节转录肽(cocaine-and amphetamine-regulated transcript,CART)是一种内源性神经肽,广泛分布于脑、胃肠道和胰腺等器官组织,具有多种重要的生理功能,包括进食与肥胖、应激、精神焦虑行为、药物成瘾和内分泌调节等.前期研究提示,CART在中枢神经系统广泛分布,并且参与调节多种生理学过程,具有一定的中枢保护作用,是一种很有潜力的神经保护剂.文章就CART对卒中以及神经变性疾病的神经保护作用及其机制,以及其在中枢神经系统疾病治疗作用等方面的研究进展进行了综述.

Protective effect of cocaine-and amphetamine-regulated transcript peptide in ischemic brain injury

Cocaine-and amphetamine-regulated transcript (CART), an endogenous neuropeptide, is widely distributed in human organs and tissues, such as brain, gastrointestinal tract and pancreas. It has a variety of important physiological functions, including eating and obesity, stress, mental anxiety, drug addition, and endocrine regulation. Previous studies have suggested that CART is widely distributed in the central nervous system, and it involves in the regulation of a variety of physiological processes and has some central protective effects. It is a potential neuroprotective agent. This article reviews the recent progress in research on the neuroprotective effect of CART on stroke and neurodegenerative disease and its mechanisms, as well as its therapeutic effect in central nervous system diseases.