Pulmonary myxoid leiomyosarcoma |
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| Authors: | Naoya Koizumi Takeaki Fukuda Yoshihisa Ohnishi Makoto Naito Iwao Emura Keiichi Sato Tatsuhiko Hirono Eiichi Suzuki |
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| Affiliation: | Second Department of Pathology, Niigata University School of Medicine, Niigata, Japan;Department of Radiology, Niigata University School of Medicine, Niigata, Japan;Department of Surgical Pathology, Niigata University Hospital, Niigata, Japan;Second Department of Surgery, Niigata University School of Medicine, Niigata, Japan;Second Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan |
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| Abstract: | A primary myxoid leiomyosarcoma arising from the peripheral bronchus of the right middle lobe was removed from a 20 year old man and examined by immunohistochemistry and electron microscopy. The tumor was well circumscribed, yellow-whitish focal polypoid growth into the bronchial lumen and consisted of spindle cells with abundant myxoid substance in the stroma. Intrapulmonary metastasis, invasion to the bronchial wall and a few mitotic figures were found. Immunohistochemically, several, but not all, tumor cells were positive against anti-vimentin, anti-S-100 protein, anti-myosin and anti-muscle specific actin. Ultrastructurally, tumor cells had thin filaments with dense bodies, pinocytic vesicles and discontinuous basal lamina. These findings indicate a myoxoid variant of leiomyosarcoma arising from mesenchyme in the peribronchial area. |
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| Keywords: | dense bodies filaments leiomyosarcoma myxoid stroma muscle specific actin |
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