血浆sTM和sICAM-1在急性冠脉综合征患者中的表达

目的：探讨血浆可溶性血栓调节蛋白（sTM）和可溶性细胞问黏附因子-1（sICAM-1）的水平在急性冠脉综合征患者（ACS组）发病中的作用。方法：用酶联免疫吸附法测定ACS组及对照组血浆sTM及sICAM-1的水平。结果：ACS组sTM水平低于对照组（P〈0．01），其中AMI组sTM水平高于UAP组，但差异无统计学意义（P〉0．05）；sICAM-1水平AMI组高于对照组和UAP组（均P〈0．01）。AMI组sTM与sICAM-1呈正相关（r=0．656，P〈0．01）。sTM及sICAM-1与肌钙蛋白Ⅰ（TnI）呈正相关（r分别为0．453和0．34，均P〈0．01）。结论：sTM、sICAM-1水平是反映ACS患者内皮细胞损伤程度和范围的良好标志。炎症反应、内皮损伤在ACS发生过程中起协同作用，炎症反应促进了急性血栓形成。

Study on the Expressions of Plasma Soluble Thrombomodulin and Soluble Intercellular Adhesion Molecule-1 in Acute Coronary Syndrome

Objective: To study the effects of plasma soluble thrombomodulin (sTM) and soluble intercellular adhesion molecule-1 (sICAM-1) levels in acute coronary syndrome (ACS) patients. Methods: The levels of sTM and sICAM-1 were examined by ELISA in ACS group and control group. Results: The level of sTM in AMI group was significantly lower than that in control group (P < 0.01). The level of sTM in AMI group was higher than that in UAP group, and there was no significant difference between the two groups (P > 0.05). The level of sICAM-1 in AMI group was significantly higher than those in control group and UAP group (P < 0.01). The level of sTM was positive correlated with sICAM-1 in AMI group (r = 0.656, P < 0.01). The levels of sTM and sICAM-1 were positive correlated with TnI in AMI group (r=0.453, r=0.342, P < 0.01). Conclusion: sTM and sICAM-1 can reflect the degree and extension of endothelial injury. Inflammation cooperates with endothelial injury in the process of ACS, and promotes the form of acute thrombosis.