大网膜脊髓移植治疗实验性脊髓损伤的研究

目的:为验证大网膜是否对脊髓损伤有修复作用。方法:本实验采用SD雌性大白鼠20只,分实验、对照两组。在同等条件及体感诱发电位监测下造成截瘫。实验组施行带蒂大网膜脊髓移植,对照组截瘫后不作任何处理。动物饲养存活3～8周后进行辣根过氧化酶逆行追踪法研究。结果:发现实验组红核内标记细胞总数为1846个,对照组为556个。P值<0.05,提示差别显著。结论:结果表明脊髓损伤后,大网膜脊髓移植对红核脊髓束神经纤维轴浆运输的恢复有促进作用,从形态学的角度进一步肯定了大网膜脊髓移植治疗外伤性截瘫的临床价值。

The study of omentum autotrans-plantation on injuried spinal cord in rats

To investigate whether the omentum autotransplantation has any benefit for repair of the spinal cord injury. Method:Twenty femal SD rats,divided into the experimental group and the control group. Under the same experimental condition and the supervision of the somatosensory evoked potential ( SEP ), paraplegia was created by injury of the spinal cord in the both animal groups. Pedicled omentum graft was transplanted immediately cover the injured cord in the experimental group. The control group was done nothing after the spinal cord injury. Retrograde horseradish peroxidase( HRP) study was carried out in the animals after 3~5 weeks of survival. Result: The statistics showed that the the number of red labeled cells was significantly differ-ente between these 2 groups ( P < 0 . 05 ). Conclusion : These results indicate that omentum au-totransplf.ntation enhances the restoration of the interrupted axial transport along the rubrospinal tract following injury, the therapeutical value of omentum transplantation for traumatic paraplegia was confirmed by the, morphologic changes.