胃癌组织中MMP-9和CD44V6表达的相互关系及其临床意义

目的　研究胃癌组织中MMP -9和CD 44V 6表达的相互关系及其临床意义。方法　采用免疫组化S -P方法 ,检测85例胃癌组织中CD44V 6和MMP -9的表达情况。结果　胃癌组织中CD44V 6阳性表达率为 47.0 6% (4 0 /85 ) ;MMP -9阳性表达率为 43 .5 3 % (3 7/85 )。胃癌组织中CD44V 6表达与MMP -9表达显著相关 (P <0 .0 5 ) ;CD44V 6和MMP -9均阳性表达与胃癌淋巴结转移、浸润深度、TNM分期及脉管浸润均呈显著正相关 (P <0 .0 5 ) ;CD 44V 6和MMP -9均阳性表达的胃癌患者术后 1、3、5年生存率分别为 5 6.2 5 %、2 8.13 %和 2 8.13 % ,其他患者术后 1、3、5年生存率分别为 89.2 5 %、71.19%和 5 9.3 3 % ,前者显著低于后者 (P均 <0 .0 5 )。结论　CD44V 6和MMP -9表达的与胃癌侵袭转移及预后显著相关

The Relationship between MMP-9 and CD44V6 Expression in Gastric Cancer and its Clinical Significance

Objective To study the relationship between the expressions of MMP 9 and CD44V6 in gastric cancer and its clinical significance.Methods The expressions of CD44V6 and MMP 9 were detected in 85 cases of gastric carcinomas by S P immunohistochemical technique.Results The positive expression rates of CD44V6 and MMP 9 were 47.06%(40/85) and 43.53%(37/85) respectively in gastric cancer.The CD44V6 expression was highly associated with MMP 9( P <0.05).The expression of CD44V6 and MMP 9 were significantly correlated with lymph node metastasis,invasive depth,the TNM stage classification and vessel invasion( P <0.05).The survival rate of patients with the both expressions of CD44V6 and MMP-9 was significantly lower than that of others patients without the expression( P <0.05).Conclusion The CD44V6 expression was correlated with MMP 9 significantly.The expressions of CD44V6 and MMP 9 were significantly correlated with invasion,metastasis and prognosis in gastric cancer.