胃癌组织中MMP-9和CD44V6表达的相互关系及其临床意义 |
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引用本文: | 张成武,裘华森,邹寿椿,赵大建.胃癌组织中MMP-9和CD44V6表达的相互关系及其临床意义[J].实用癌症杂志,2003,18(2):158-160. |
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作者姓名: | 张成武 裘华森 邹寿椿 赵大建 |
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作者单位: | 310014,浙江省人民医院 |
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摘 要: | 目的 研究胃癌组织中MMP -9和CD 44V 6表达的相互关系及其临床意义。方法 采用免疫组化S -P方法 ,检测85例胃癌组织中CD44V 6和MMP -9的表达情况。结果 胃癌组织中CD44V 6阳性表达率为 47.0 6% (4 0 /85 ) ;MMP -9阳性表达率为 43 .5 3 % (3 7/85 )。胃癌组织中CD44V 6表达与MMP -9表达显著相关 (P <0 .0 5 ) ;CD44V 6和MMP -9均阳性表达与胃癌淋巴结转移、浸润深度、TNM分期及脉管浸润均呈显著正相关 (P <0 .0 5 ) ;CD 44V 6和MMP -9均阳性表达的胃癌患者术后 1、3、5年生存率分别为 5 6.2 5 %、2 8.13 %和 2 8.13 % ,其他患者术后 1、3、5年生存率分别为 89.2 5 %、71.19%和 5 9.3 3 % ,前者显著低于后者 (P均 <0 .0 5 )。结论 CD44V 6和MMP -9表达的与胃癌侵袭转移及预后显著相关
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关 键 词: | 胃癌 CD44拼接变异体V6 基质金属蛋白酶-9 预后 |
文章编号: | 1001-5930(2003)02-0158-03 |
修稿时间: | 2002年8月2日 |
The Relationship between MMP-9 and CD44V6 Expression in Gastric Cancer and its Clinical Significance |
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Abstract: | Objective To study the relationship between the expressions of MMP 9 and CD44V6 in gastric cancer and its clinical significance.Methods The expressions of CD44V6 and MMP 9 were detected in 85 cases of gastric carcinomas by S P immunohistochemical technique.Results The positive expression rates of CD44V6 and MMP 9 were 47.06%(40/85) and 43.53%(37/85) respectively in gastric cancer.The CD44V6 expression was highly associated with MMP 9( P <0.05).The expression of CD44V6 and MMP 9 were significantly correlated with lymph node metastasis,invasive depth,the TNM stage classification and vessel invasion( P <0.05).The survival rate of patients with the both expressions of CD44V6 and MMP-9 was significantly lower than that of others patients without the expression( P <0.05).Conclusion The CD44V6 expression was correlated with MMP 9 significantly.The expressions of CD44V6 and MMP 9 were significantly correlated with invasion,metastasis and prognosis in gastric cancer. |
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Keywords: | Gastric cancer CD44 splice variant V6(CD44V6) Matrix metalloproteinase 9(MMP 9) Prognosis |
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