抗流行性乙型脑炎病毒药物的筛选试验

以47种药物对小鼠流行性乙型脑炎进行实验治疗,发现其中苯乙肼、呋喃西林、8-氮杂鸟嘌呤、氨硫脲、丙基麻黄碱、去氧麻黄碱、苯肼、异烟肼、6-巯嘌呤等9种药物能降低感染病毒小鼠的死亡率,其余38种药物无效。苯乙肼与呋喃西林且能抑制流行性乙型脑炎病毒在鼠脑繁殖,体外试验均有直接抗病毒作用。对有效药物的化学结构与抗病毒作用关系进行了初步研究,发现肼的苯环化合物,半缩脲的环状化合物,麻黄碱类似物,嘌呤拮抗物,可作为筛选抗流行性乙型脑炎病毒药物的线索。

SCREENING TEST OF ANTI-JAPANESE B ENCEPHALITIS VIRUS DRUGS

1. Out of forty-seven kinds of drugs experimentally tested in mice infected with Japanese B encephalitis virus, 9 were shown to possess certain therapeutic effects; they are phenelzine, funacillin, 8-azaguanine, thiosemicarbazide, propadrine, deoxyephedrine, phenylhydrazine, isonicotinylhydrazide, 6-MP. 2. Of particular interest was the observation that phenelzine and funacillin inhibited the multiplication of Japanese B encephalitis virus in mouse brain. 3. By analysing the relationship between chemical structures and therapeutic actions of such effective substances as hydrazine benzyl compounds, cyclo semicarbazide, ephedrine analogues, anti-purine compounds, it is reasonablly expected that those compounds may be used as tools for further studies to throw additional light on the chemotherapeutic mechanism of action against Japanese B encephalitis virus.