| 抗环瓜氨酸肽(CCP)抗体与类风湿关节炎病情活动度及关节损害的关系探讨 |
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| 引用本文： | 徐巍,沈波,陈世勇,李俊,袁兆林,张晓雪.抗环瓜氨酸肽(CCP)抗体与类风湿关节炎病情活动度及关节损害的关系探讨[J].中国卫生检验杂志,2010(1). |
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| 作者姓名： | 徐巍 沈波 陈世勇 李俊 袁兆林 张晓雪 |
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| 作者单位： | 浙江省台州医院; |
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| 基金项目： | 浙江省医药卫生科技计划资助项目(2007B225) |
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| 摘 要： | 目的:分析抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断和评估意义,探讨抗CCP抗体与RA的病情活动度、关节侵蚀的关系。方法:用ELISA检测32例RA患者血清和关节液中的抗CCP抗体,并测定类湿因子(RF),记录RA患者的一些临床参数。对检测结果及临床参数进行统计分析。结果:抗CCP抗体阳性组与阴性组相比,年龄、关节肿胀个数、关节疼痛个数、DAS28、血沉及CRP等没有显著性差异(P0.05);类风湿因子的阳性率在两组间的差异有统计学意义(P0.05)。抗CCP抗体与年龄、关节肿胀个数、关节疼痛个数、DAS28、ESR和CRP等相关无显著性差异;抗CCP抗体与RF因子呈明显相关(r=0.639,P=0.001)。DAS28评分与关节肿胀个数、关节疼痛个数、DAS28、ESR和CRP显著相关,与年龄因素呈正相关,与类风湿因子的相关无统计学意义。结论:抗CCP抗体对RA的预后有一定的评估作用。
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| 关 键 词： | 抗环瓜氨酸肽抗体 类风湿关节炎 |
Relation of CCP antibody to mobility and damage of joints in patients with rheumatoid arthritis |
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| XU Wei,SHEN Bo,CHEN Shi-yong,LI Jun,YUAN Zhao-lin,ZHANG Xiao-xue.Relation of CCP antibody to mobility and damage of joints in patients with rheumatoid arthritis[J].Chinses Journal of Health Laboratory Technology,2010(1). |
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| Authors: | XU Wei SHEN Bo CHEN Shi-yong LI Jun YUAN Zhao-lin ZHANG Xiao-xue |
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| Institution: | XU Wei,SHEN Bo*,CHEN Shi-yong,LI Jun,YUAN Zhao-lin,ZHANG Xiao-xue (Taizhou Hospital,Taizhou 317000,China) |
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| Abstract: | Objective:To determine the value of determination of CCP antibody for diagnosis and evaluation of rheumatoid arthritis(RA).Methods:ELLISA was used to determine CCP antibody in 32 patients with RA.Meanwhile,RF was determined and relevant clinical parameters recorded.Then statistical analysis of the data was performed.Results:There was no significant difference in age,joint damage number,joint pain,DAS28 and other indexes between the RA patients and controls(P>0.05).There was marked difference in RF positive ... |
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| Keywords: | CCP antibody Rheumatoid arthritis |
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