雌孕激素受体与女性原发乳腺癌术后复发转移关系的临床研究

目的:分析乳腺癌患者雌激素受体(es-trogen receptor,ER)和孕激素受体(progesteronereceptor,PR)状态与术后复发、转移部位的关系。方法:1989~1994年经天津医科大学附属肿瘤医院收治乳腺癌病例且雌、孕激素受体明确、术后随访完整的病例1372例。根据ER和PR状态分组,总结ER和PR状态与首次治疗后发生复发、转移部位的关系。结果:ER /PR 组患者皮肤、骨骼转移率为10·91%,明显高于ER-/PR-组(5·56%),P=0·0053;ER-/PR-组内脏转移率为15·56%,高于ER /PR 组(3·64%),P=0·0000。激素依赖性组5年总生存率和无瘤生存率(82·31%,80·04%)高于非激素依赖性组(77·22%,73·89%),P<0·05。两组10年总生存率、无瘤生存率并无区别。结论:乳腺癌在晚期转移部位与ER、PR受体状态有关,ER /PR 组5年总生存率、无瘤生存率高于ER-/PR-组,进行综合治疗是提高总生存率、无瘤生存率的关键。

Clinical research on ER, PR status with recurrence and distant metastatic site in primary breast cancer

OBJECTIVE:To analyze the ER, PR status of breast cancer with the recurrence and distant metastatic site following radical mastectomy. METHODS:A total of 1 372 patients treated in Tianjin Cancer Hospital, and with entire ER, PR status and follow-up records were studied. These cases were devided into two groups according to the ER,PR status. The hormone status' relationship between the recurrence and distant metastatic site was discussed. RESULTS: The rate of bone metastasis in breast cancer patients with ER /PR was higher than that of patients with ER-/PR-(P=0.005 3), the vercercal metastasis was more seen in the ER-/PR- patients than that in the ER /PR patients, P= 0.000 0 . The 5-year total survival and DFS rates in hormone dependent group (82.31%,80.04%) were higher than those in the non hormone group (77.22%,73.89%),P<0.05. The 10-year total survival and DFS rate had no significant difference between the two groups. CONCLUSIONS: The breast cancer can be of metastases in blood of advanced stage. The metastatic site is correlated with the ER, PR status, and the 5-year total survival and DFS rate are higher in the ER /PR group than those in the ER-/PR- group. The combined treatment can raise the survival rate.