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Ghrelin的发现及研究进展
引用本文:王越晖,祝世功. Ghrelin的发现及研究进展[J]. 中国病理生理杂志, 2001, 17(12): 1256-1259
作者姓名:王越晖  祝世功
作者单位:北京大学医学部生理学与病理生理学系,北京 100083
基金项目:科技部973计划资助项目(No.200056908)
摘    要:Ghrelin是一个新发现的由 2 8个氨基酸组成内源性肽 ,它可与生长素促泌物受体 (growthhormonesecretagoguereceptor,GHSR)结合促进生长素 (growthhormone ,GH)分泌。Ghrelin是目前为止除了生长素释放激素 (growthhormonereleasinghormone ,GHRH)和生长抑素 (somatostatin ,SS)外 ,第三个调节腺垂体GH分泌的内源性物质。根据对目前已积累的 90多篇研究资料来分析 ,ghrelin除调节GH分泌外 ,对其它器官系统也具…

关 键 词:受体  促生长素  内分泌学  
文章编号:1000-4718 (2001)12-1256-04
收稿时间:2001-10-17
修稿时间:2001-10-17

Discovery and research progress of ghrelin
WANG Yue-hui,ZHU Shi-gong. Discovery and research progress of ghrelin[J]. Chinese Journal of Pathophysiology, 2001, 17(12): 1256-1259
Authors:WANG Yue-hui  ZHU Shi-gong
Affiliation:Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
Abstract:Ghrelin is a novel growth hormone-releasing acylated brain-gut peptide, consisting of 28 amino acids, discovered and isolated from stomach.Ghrelin stimulates the release of growth hormone (GH )through the binding with growth hormone secretagogue receptor (GHSR) in the hypothalamus and anterior pituitary. The intensive results imply that ghrelin exists in brain and gastrointestinal tract, and that many other cells can secret ghrelin. Functionaly, ghrelin not only increase the GH release, but also is related to body growth , energy metabolism, endocrine, blood circulation and some diseases.
Keywords:Receptors   somatotropin  Endocrinology
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