| 绞股蓝总皂甙对2型糖尿病大鼠脑神经生长因子基因表达的影响 |
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| 引用本文： | 包海花 郭新民 聂影 崔荣军. 绞股蓝总皂甙对2型糖尿病大鼠脑神经生长因子基因表达的影响[J]. 中国康复医学杂志, 2006, 21(4): 328-329 |
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| 作者姓名： | 包海花 郭新民 聂影 崔荣军 |
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| 作者单位： | 牡丹江医学院,黑龙江,牡丹江,157011 |
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| 摘 要： | 目的：研究绞股蓝总皂甙（Gps）对2型糖尿病大鼠脑神经生长因子（nerve growth factor,NGF）mRNA表达的影响.方法：随机选取以不同剂量的Gps灌胃的2型糖尿病大鼠,以生理盐水灌胃的2型糖尿病大鼠及正常对照组大鼠各10只,用RT-PCR法测定脑神经生长因子mRNA的表达.结果：2型糖尿病大鼠脑神经生长因子mRNA表达下降,服用绞股蓝总皂甙的2型糖尿病大鼠脑神经生长因mRNA表达上调.结论：绞股蓝总皂甙能增加2型糖尿病大鼠脑神经生长因子基因的表达.
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| 关 键 词： | 绞股蓝总皂甙 2型糖尿病大鼠 神经生长因子 基因表达 |
| 文章编号： | 1001-1242(2006)-04-0328-02 |
| 收稿时间： | 2005-07-05 |
| 修稿时间： | 2005-07-05 |
Effect of Gypenosides preparation on expression of nerve growth factor gene of cerebrum in type 2 diabetic rats |
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| BAO Haihu,GUO Xinmin,NIE Ying. Effect of Gypenosides preparation on expression of nerve growth factor gene of cerebrum in type 2 diabetic rats[J]. China Journal of Rehabilitation Medicine, 2006, 21(4): 328-329 |
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| Authors: | BAO Haihu GUO Xinmin NIE Ying |
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| Affiliation: | Mudanjiang Medical College, Mudanjiang, Heilongjiang Province, 157011 |
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| Abstract: | Objective:To study the effect of Gypenosides on the expression of the brain nerve growth factor mRNA in type 2 diabetic rats.Method:Selecting type 2 diabetic rats with gastric filling of various dosage of Gypenosides and Physiological saline, ten rats in each group and ten normal rats as control, the expression of brain NGF mRNA was measured with by RT-PCR. Result:The mRNA expression of Brain NGF in type 2 diabetic groups were lower than that of normal group(P<0.05),and the Gypenosides groups were higher than that of type 2 diabetic model(P<0.05).Conclusion:Gypenosides can increase the mRNA expression of brain NGF in type 2 diabetic rats. |
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| Keywords: | Gypenosides type 2 diabetic rats nerve growth factor gene expression |
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