| 阿莫西林片的人体相对生物利用度研究 |
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| 引用本文： | 刘会臣 胡玉钦. 阿莫西林片的人体相对生物利用度研究[J]. 中国医药工业杂志, 1999, 30(6): 255-257 |
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| 作者姓名： | 刘会臣 胡玉钦 |
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| 作者单位： | 白求恩国际和平医院临床药理室 |
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| 摘 要： | 以高效液相色谱法测定了人血清中阿莫西林，以进口阿莫西林片为参比制剂，研究了国产阿莫西林片的相对生物利用度。结果表明，国产和进口片的药－时曲线均符合一级吸收的二房室模型，两药的药代动力学参数间均无显著性差异，国产片的相对生物利用度为９９．１％。
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| 关 键 词： | 阿莫西林 高效液相色谱 相对生物利用度 |
STUDY ON RELATIVE BIOAVAILABILITY OFDOMESTIC AMOXICILLIN TABLETS |
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| LIU HuiChen ,HU YuQin,MA Rui,LI XinFang,HOU YanNing=. STUDY ON RELATIVE BIOAVAILABILITY OFDOMESTIC AMOXICILLIN TABLETS[J]. , 1999, 30(6): 255-257 |
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| Authors: | LIU HuiChen HU YuQin MA Rui LI XinFang HOU YanNing= |
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| Affiliation: | LIU HuiChen *,HU YuQin,MA Rui,LI XinFang,HOU YanNing= |
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| Abstract: | A HPLC method was used for determination of amoxicillin in human serum.The relative bioavailability of domestic amoxicillin tablets was studied in 8 healthy volunteers and was compared with an imported product.The results showed that there was no significant difference in pharmacokinetic parameters between them.The relative bioavailability of the domestic tablets was 99.1%.= |
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| Keywords: | amoxicillin HPLC pharmacokinetics relative bioavailability= |
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