| 尼群地平胶丸的研制 |
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| 引用本文： | 王艳娇,布献毅.尼群地平胶丸的研制[J].中国医药工业杂志,1999,30(6):252-255. |
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| 作者姓名： | 王艳娇 布献毅 |
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| 作者单位： | [1]沈阳康达制药厂 [2]北京毅军医院技术公司 |
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| 摘 要： | 采用聚乙二醇４００制备了尼群地平软胶丸，其体外溶出度高于市售片剂。９名健康受试者交叉口服胶丸剂和片剂，胶丸剂的达峰时间（Ｔｍａｘ）提前，峰浓度（Ｃｍａｘ）增高，药时曲线下面积（ＡＵＣ）值增加，经统计学分析，两制剂的生物利用度有显著性差异。
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| 关 键 词： | 尼群地平 胶丸 溶出度 生物利用度 降压药 |
PREPARATION OF NITRENDIPINE SOFT CAPSULES |
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| Authors: | WANG YanJiao BU XianYia ZHANG TianHongb TANG Xingc |
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| Institution: | WANG YanJiao,BU XianYia,ZHANG TianHongb,TANG Xing*c |
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| Abstract: | Nitrendipine soft capsules were prepared using PEG400.The results of evaluation in vitro/in vivo showed that their dissolution rate and bioavailability in nine healthy volunteers were significantly higher than commercial tablets. |
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| Keywords: | nitrendipine soft capsules dissolution bioavailability |
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