| 左氧氟沙星注射剂含量及有关物质的HPLC测定 |
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| 引用本文： | 雷嘉川 何光明. 左氧氟沙星注射剂含量及有关物质的HPLC测定[J]. 中国医药工业杂志, 1999, 30(6): 269-270 |
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| 作者姓名： | 雷嘉川 何光明 |
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| 作者单位： | 湖北医科大学药学系 |
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| 摘 要： | 以反相高效液相色谱法测定左氧氟沙星注射剂的含量及有关物质。采用Ｗａｔｅｒｓ Ｎｏｖａ－ＰａｋＣ１８柱，１０ｍｍｏｌ／Ｌ ＫＨ２ＰＯ４－１０ｍｍｏｌ／Ｌ溴化四丁铵－乙腈（４５：４５：１０，磷酸调节ｐＨ２．８）为流动相，检测波长为２９３ｎｍ。平均回收率为１００．５％，ＲＳＤ为０．７１％。方便简便、准确。
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| 关 键 词： | 左氧氟沙星 高效液相色谱 有关物质 测定 |
DETERMINATION OF LEVOFLOXACIN INJECTION AND =RELATED SUBSTANCES BY HPLC |
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| LEI JiaChuan,HE GuangMing,YU JianQing,ZHOU YanAn. DETERMINATION OF LEVOFLOXACIN INJECTION AND =RELATED SUBSTANCES BY HPLC[J]. , 1999, 30(6): 269-270 |
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| Authors: | LEI JiaChuan HE GuangMing YU JianQing ZHOU YanAn |
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| Affiliation: | LEI JiaChuan*,HE GuangMing,YU JianQing,ZHOU YanAn |
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| Abstract: | A reverse phase HPLC method was described for determination of levofloxacin injection and related substances. Waters NovaPak C18 column(3.9150 mm,4 m) and mobile phase, 10 mmol/L KH2PO410 mmol/L(C4H9)4NBrCH3CN(454510,pH2.8), were used. Detection wavelength was 293 nm. The average recovery was 100.5% with RSD of 0.71%. |
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| Keywords: | levofloxacin HPLC injection related substances determination |
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