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Effect of Ca++ and GABA on oxidation of glutamate and glutamine by rat brain synaptosomes
Authors:N. S. Nilova
Abstract:Experiments in vitro showed that the addition of Ca++ inhibits respiration of rat brain synaptosomes in the presence of glutamate and glutamine. The addition of GABA potentiates the inhibitory effect of Ca++ on the oxidation of glutamine but not of glutamate. GABA itself has no effect on the oxidation of either glutamate or glutamine.Laboratory of Functional Neurochemistry, I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR V. N. Chernigovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 9, pp. 293–295, September, 1978.
Keywords:synaptosomes  oxidation  glutamine  glutamate    /content/k7425n5rq29674r3/xxlarge947.gif"   alt="  gamma"   align="  MIDDLE"   BORDER="  0"  >-aminobutyric acid
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