| 丹参与环磷酰胺治疗小鼠白血病心脏浸润的实验研究 |
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| 引用本文： | 王莹,王广. 丹参与环磷酰胺治疗小鼠白血病心脏浸润的实验研究[J]. 中国中西医结合杂志, 2004, 0(Z1) |
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| 作者姓名： | 王莹 王广 |
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| 作者单位： | 北京市海淀医院，北京大学第三医院 北京100080) |
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| 摘 要： | 目的比较化疗药物环磷酰胺(CTX)加丹参与 CTX 治疗小鼠白血病心脏浸润的疗效。方法建立小鼠白血病模型(L615),用羟脯氨酸检验试剂盒测定小鼠心肌羟脯氨酸含量。以 N-乙酰半胱氨酸激活法检测小鼠心肌肌酸肌酶含量。结果 CTX 加丹参组比 CTX 组小鼠的白血病细胞心脏浸润率明显降低(P<0.05),羟脯氨酸及肌酸肌酶含量 CTX 加丹参组较 CTX 组明显降低(P<0.05)。结论 CTX 加丹参组较单纯CTX 治疗白血病心脏浸润更有效。
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| 关 键 词： | 白血病心脏浸润 化疗 丹参 羟脯氨酸 |
Treatment of Leukemia with Heart Infiltration by Salviae MilfioIThiza |
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| WANG Ying WANG Guang Beijing Haidian Hospital,Beijing. Treatment of Leukemia with Heart Infiltration by Salviae MilfioIThiza[J]. Chinese journal of integrated traditional and Western medicine, 2004, 0(Z1) |
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| Authors: | WANG Ying WANG Guang Beijing Haidian Hospital Beijing |
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| Abstract: | Objective To compare the therapeutic efficacy of cyclophosphamide(CTX)alone and combination of CTX and salviae miltiorrhiza(CTX-SM)in treating leukemia with heart infiltration(LHI).Methods Mice model of leukemia(L615)were es- tablished.Myocardial content of hydroxyproline(HP)was detected by test kit,and that of creatine kinase(CK)tested by N- acetylcysteine activation method.Results The heart infiltration,and the myocardial contents of HP and CK were significantly lowered in the model mice treated by CTX-SM than those in model mice treated by CTX alone(P<0.05).Conclusion The combined therapy by CTX-SM is more effective than by CTX alone in treating heart infiltration of leukemia. |
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| Keywords: | leukemia with heart infiltration chemotherapy salviae miltiorrhiza hydroxyproline |
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