| EB病毒潜伏膜蛋白1的研究进展 |
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| 引用本文： | 陈育华,周克元,袁汉尧. EB病毒潜伏膜蛋白1的研究进展[J]. 医学综述, 2009, 15(2): 170-173 |
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| 作者姓名： | 陈育华 周克元 袁汉尧 |
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| 作者单位： | 1. 广东医学院附属医院检验科,广东湛江,524001
2. 广东医学院生物化学与分子牛物学研究所,广东湛江,524023 |
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| 摘 要： | EB病毒潜伏膜蛋白1(LMP1)是EB病毒编码的一种主要蛋白,它能通过其C末端的3个功能结构域CTAR1、CTAR2及CTAR3启动一系列信号途径,包括核因子κB、PI3K-Akt/PAB、MAPK及JAKs/STATs,从而调节其宿主细胞的生长、增殖、分化、凋亡等多种细胞生物学功能,本文就这方面的研究进展及其自身调节的机制综述如下。
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| 关 键 词： | 潜伏膜蛋白 细胞信号 自身调节 |
Study Progress of Epstein-Barr Virus Latent Membrane Protein 1 |
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| CHEN Yu-hua,ZHOU Ke-yuan,YUAN Han-yao. Study Progress of Epstein-Barr Virus Latent Membrane Protein 1[J]. Medical Recapitulate, 2009, 15(2): 170-173 |
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| Authors: | CHEN Yu-hua ZHOU Ke-yuan YUAN Han-yao |
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| Affiliation: | CHEN Yu-hua , ZHOU Ke- yuan, YUAN Han-yao ( 1. Department of Clinical Laboratory,Affiliated Hospital, Guangdong Medical College ,Zhanjian 524001, China; 2. Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjian 524023, China) |
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| Abstract: | Epstein-Barr virus latent membrane protein 1 （ LMP1 ）, which is a major protein encoded by EB virus, can adjust growth, proliferation, differentiation, apoptosis and other biological functions of its host cell by launching a series of signal channels including the NF-κB, PI-3K-Akt/PKB ,MAPK and JAKs/STATs through its three functions of the C-terminal domain CTAR1, CTAR2 and CTAR3. This article reviews the related progress and its antogenous regulation mechanism. |
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| Keywords: | Latent membrane protein 1 Cell signaling Self-regulation |
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