| 黏球菌产生的活性天然产物 |
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| 引用本文： | 刘新利,鞠培殿,娄红祥.黏球菌产生的活性天然产物[J].国外医学(药学分册),2010(2):98-104. |
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| 作者姓名： | 刘新利 鞠培殿 娄红祥 |
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| 作者单位： | 山东大学药学院药学博士后流动站;山东轻工业学院;山东省微生物工程重点实验室; |
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| 基金项目： | 山东省自然科学基金(Y2008D18);;山东省博士后创新项目专项资金(200903077) |
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| 摘 要： | 从化学结构、生物学活性、生物合成、应用开发等角度,综述了已有文献报道的黏球菌活性天然产物,重点介绍了作用于肌动蛋白的大环内酯类化合物rhizopodin、作用于呼吸链的肽类化合物myxothiazol和多烯类化合物myxalamid、作用于核酸的芳香类化合物myxopyronin和saframycin Mx1,以及作用于细胞壁的大环类化合物myxovirescin,阐明了黏球菌次级代谢产物的化学结构多样性和生物活性多样性,为进一步开发黏球菌活性天然产物提供线索。
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| 关 键 词： | 黏细菌 黏球菌属 次级代谢产物 活性机制 |
Bioactive natural products produced by Myxococcus |
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| LIU Xin-li ,JU Pei-dian ,LOU Hong-xiang.Bioactive natural products produced by Myxococcus[J].Foreign Medical Sciences(Section of Pharmarcy),2010(2):98-104. |
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| Authors: | LIU Xin-li JU Pei-dian LOU Hong-xiang |
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| Institution: | 1.School of Pharmaceutical Science;Shandong University;Jinan 250014;China;2.Shandong Provincial Key Laboratory of Microbial Engineering;Shandong Institute of Light Industry;Jinan 250353;China |
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| Abstract: | The chemical structure,biological activity,biosynthesis and application of metabolites of Myxococcus published in literature are summarized in this paper.Emphasis is laid on the actin-binding macrolide rhizopodin,the respiratory chain inhibitors peptide myxothiazol and polyenoid myxalamid,the aromatic compound myxopyronin and saframycin Mx1 acting on nucleic acid,and the macrocyclic compound myxovirescin interfering with cell wall.This review clarifies the diversity of the chemical structure and bio-logical... |
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| Keywords: | myxobacteria Myxococcus secondary metabolite bioactivity mechanism |
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