HER2与p16在子宫内膜癌中的表达及临床意义

目的探讨HER2和p16在子宫内膜癌中的表达及其与肿瘤FIGO分期、分化程度的关系。方法子宫内膜癌46例、不典型增生10例、子宫内膜增生过长10例、正常子宫内膜20例，应用免疫组织化学法对HER2和p16的表达情况进行分析。结果HER2在子宫内膜癌组织中的表达明显高于非癌组织，差异有统计学意义（P〈0．01）；其表达随临床分期的增加而明显增强（P〈0．05），随分化程度的降低而增强（P〈0．05）。p16在子宫内膜癌组织中的表达明显低于非癌组织，差异有统计学意义（P〈0．05）。其表达随临床分期的增加而明显减弱（P〈0．01），随分化程度的降低而明显降低（P〈0．05）。HER2和p16表达呈负相关性（r=-0．4213，P〈0．01）。结论HER2和p16在子宫内膜癌中的表达与内膜癌的生物学行为有关，可作为子宫内膜癌预后的指标，指导子宫内膜癌术后的治疗。

Expression and clinical significance of HER2 and p16 in endometrial carcinoma

Objective To study the expressions of HER2 and p16 in human endometrial carcinoma, and the relation with FIGO stage, cell differentiated degree. Methods Endometrial cancer was 46 cases, atypical hyperplasia was 10 cases, endometrial hyperplasia was 10 cases, normal endometrium was 20 cases. The immunohistochemical S-P methods were used to detect the expression of HER2 and p16. Results The expression of HER2 in endometrial cancer was much higher than others （P 〈 0.01 ）, moreover, the ex-pression was increased with the increase of clinical stages（P 〈 0.05 ） and the decrease of differentiated degree （P 〈 0.05）. The expression of p 16 in endometrial cancer was lower than others （P 〈 0.05 ）, and the expression was reduced with the increase of clinical stages（P 〈 0.01 ） and the decrease of differentiated degree（P 〈 0.05）.There was negative correlation between expression of HER2 and p16 in uterine endometrial cancer （r = -0.4213, P〈 0.01 ）. Conclusions The expression of HER2 and p16 in endometrial cancer is associated with the biological behavior of endometrial cancer. HER2 and p16 may be used as objective predictable indicators of endometrial cancer to guide the postoperative treatment.