人类巨细胞病毒潜伏-再活化感染对乙型肝炎患者疾病演变的影响研究 |
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引用本文: | 李成德,李海珠,梁莉红,李南洋. 人类巨细胞病毒潜伏-再活化感染对乙型肝炎患者疾病演变的影响研究[J]. 中国医师进修杂志, 2008, 0(4): 27-29 |
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作者姓名: | 李成德 李海珠 梁莉红 李南洋 |
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作者单位: | 广东省肇庆市第一人民医院检验科,526021 |
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摘 要: | 目的 探讨人类巨细胞病毒(HCMV)潜伏-再活化感染对乙型肝炎患者疾病演变的影响。方法 随机选取162例HBsAg呈阳性的肝病患者血清,实时荧光PCR定量法检测其HCMV—DNA和HBV—DNA含量,ELISA法检测其HCMV—IgG、IgM水平。结果HCMV—DNA和HCMV—IgM两者的阳性率及HCMV—DNA定量均值较一致:对照者〈乙型肝炎患者〈肝硬化患者〈肝癌患者;乙型肝炎HBV—DNA阳性患者与乙型肝炎HBV—DNA阴性患者间的HCMV—DNA阳性率和HCMV—IgM阳性率比较差异均有统计学意义(P〈0.01)。结论 在多重感染状态下,HCMV潜伏-再活化感染与乙型肝炎疾病演变有一定的关联。
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关 键 词: | 肝炎 乙型 巨细胞病毒 潜伏-再活化感染 |
The influence of infection again to hepatitis B sufferer get disease turn into by human cytomegalovirus afterbirth incubates-activate |
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Affiliation: | LI Cheng-de, LI Hai-zhu, LIANG Li-hong, LI Non- yang.(Department of Clinical Laboratory, The First People's Hospital of Zhaoqing City, Guangdong Zhaoqing 526021, China) |
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Abstract: | Objective To study the influence of infection again to hepatitis B sufferer get disease turn into by human cytomegalovirus (HCMV) afterbirth incubates-activate. Methods The serum levels of HCMV-DNA and HBV-DNA were determined by real-time fluorescent ration PCR, and the HCMV-IgG, IgM level were determined by ELISA in 162 serums from hepatitis patients HBsAg reported the masculine. Results The masculine rate of HCMV-DNA and HCMV-IgM, and the mean value of HCMV-DNA ration were much consilient: controls 〈 hepatitis B sufferer 〈 hepatocirrhosis 〈 hver cancer. The masculine rate of HCMV-DNA and HCMV-IgM in hepatitis B HBV-DNA positive patients was higher in hepatitis B HBV-DNA negative patients(P 〈 0.01 ). Conclusion Under the multiple infection appearance, it has the certain association with connection which HCMV afterbirth incubatesactivate the infection again to hepatitis B get disease turn into. |
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Keywords: | Hepatitis B Cytomegalovirus Incubate-activate the infection again |
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