Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants |
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| Authors: | Sudha P Smita S Zinjarde Shobha Y Bhargava Ameeta R Kumar |
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| Institution: | (1) Institute of Bioinformatics and Biotechnology, University of Pune, 411 007 Pune, India;(2) Molecular Embryology Laboratory, Department of Zoology, University of Pune, 411 007 Pune, India |
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| Abstract: | Background Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic
agents. Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via
control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected
to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential
on PPA (porcine pancreatic α-amylase). Preliminary phytochemical analysis of the lead extracts was performed in order to determine
the probable constituents. |
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