| 白芍中芍药苷及其衍生物的UPLC-MS/MS分析 |
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| 引用本文： | 郑敏霞,陈喆,刘培,葛宇清,代群. 白芍中芍药苷及其衍生物的UPLC-MS/MS分析[J]. 中国中药杂志, 2011, 36(12): 1641-1643 |
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| 作者姓名： | 郑敏霞 陈喆 刘培 葛宇清 代群 |
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| 作者单位： | 浙江中医药大学附属第一医院国家中医临床研究基地,浙江杭州,310006 |
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| 基金项目： | 国家自然科学基金项目(30600280) |
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| 摘 要： | 目的:采用超高效液相色谱与四级杆-线性离子阱串联质谱联用技术(UPLC-Q-Trap MS-MS)对白芍中单萜糖苷类成分进行分析和鉴别.方法:用Acquity UPLC BEH C18色谱柱,以0.1%甲酸水溶液(A)乙腈(B)为流动相梯度洗脱,使用ESI离子源,在负离子模式下采集数据,数据采集范围m/z100～1200,雾化气124.¨kPa,脱溶剂气103.43 kPa,气帘气206.85kPa;离子源温度为450℃;离子喷雾电压为-4.5 kV;结果:白芍中化学成分获得了较好的分离和检测,共推测出6个糖苷类化合物的化学结构;结论:该方法灵敏度高,分离度好,适用于白芍中单萜糖苷类成分的快速分析与结构鉴定.
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| 关 键 词： | 白芍 单萜糖苷 超高效液相色谱质谱联用法 |
| 收稿时间： | 2010-11-21 |
Analysis and identification of glycosides in Paeonia lactiflora by UPLC-MS/MS |
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| ZHENG Minxi,CHEN Zhe,LIU Pei,GE Yuqing and DAI Qun. Analysis and identification of glycosides in Paeonia lactiflora by UPLC-MS/MS[J]. China Journal of Chinese Materia Medica, 2011, 36(12): 1641-1643 |
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| Authors: | ZHENG Minxi CHEN Zhe LIU Pei GE Yuqing DAI Qun |
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| Affiliation: | National Clinical Research Base of Traditional Chinese Medicine, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China;National Clinical Research Base of Traditional Chinese Medicine, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China;National Clinical Research Base of Traditional Chinese Medicine, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China;National Clinical Research Base of Traditional Chinese Medicine, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China;National Clinical Research Base of Traditional Chinese Medicine, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China |
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| Abstract: | |
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| Keywords: | Paeonia lactiflora monoterpene glycoside UPLC-MS/MS |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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