| 中药浸膏粉物理性质与干法制粒工艺的相关性研究 |
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| 引用本文： | 李洁,杜若飞,冯怡,徐德生,阮克锋.中药浸膏粉物理性质与干法制粒工艺的相关性研究[J].中国中药杂志,2011,36(12):1606-1609. |
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| 作者姓名： | 李洁 杜若飞 冯怡 徐德生 阮克锋 |
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| 作者单位： | 1. 上海中医药大学中药现代制剂技术教育部工程研究中心,上海,201203
2. 上海中医药大学附属曙光医院,上海,200021 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09502-009);上海市科委项目(09DZ2292000);上海高校选拔培养优秀青年教师科研专项基金(szy08046);上海市教委重点学科项目(J50302) |
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| 摘 要： | 目的:通过探讨中药浸膏粉物理性质和制粒工艺参数与干法制粒颗粒质量的相关性,找出影响制粒效果的主要因素.方法:应用多元线性回归分析方法考察浸膏粉的休止角、压缩度、黏聚力、含水量等物理性质,制粒工艺中的送料速度、滚轮转速、滚轮压力等参数与颗粒剂得率的相关关系.结果:压缩度、含水量、送料速度、滚轮压力均与干法制粒颗粒的得率呈明显的正相关关系,休止角、黏聚力、滚轮转速均与干法制粒颗粒的得率呈明显的负相关关系.结论:中药浸膏粉物理性质和干法制粒的工艺参数是影响干法制粒的主要因素,其中药浸膏物理性质参数压缩度、黏性以及制粒工艺参数中滚轮转速对干法制粒的效果影响较大.
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| 关 键 词： | 中药浸膏粉 干法制粒 多元回归分析 |
| 收稿时间： | 2011/3/17 0:00:00 |
Correlation of physical properties of herbal extracts and dry granulating process |
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| LI Jie,DU Ruofei,FENG Yi,XU Desheng and RUAN Kefeng.Correlation of physical properties of herbal extracts and dry granulating process[J].China Journal of Chinese Materia Medica,2011,36(12):1606-1609. |
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| Authors: | LI Jie DU Ruofei FENG Yi XU Desheng and RUAN Kefeng |
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| Institution: | Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China;Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China |
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| Abstract: | Objective : To study the correlation of dry granulation with Chinese extract powder physical properties and dry granulating process parameters to find out the main factors affecting the granulation progress. Method :The correlation with the physical properties including angle of repose,compression degree,cohesion,water content, feeding speed, wheel speed and wheel pressure with the yield of grain was investigated by multiple regression analysis. Result : The results showed that compression degree, water content, feeding speed and wheel pressure was positively correlated with the yield of grain in measured range.The angle of repose, cohesion, wheel speed was negative correlated with the yield of grain in measured range. Conclusion : Dry granulating was highly influenced by the physical properties of herbal extracts and the parameters of dry granulating process.The greater impact on grain dry method are compression,cohesion and wheel speed. |
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| Keywords: | Chinese extract powder grain dry multiple regression analysis |
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